1-(4-硝基苯基)环戊烷羧酸合成路线 （共 5 条）
反应条件
1: SOCl2 / benzene / 4 h / Heating 2: benzene / 4 h / Heating View Scheme
参考文献
Hudkins, Robert L.; DeHaven-Hudkins, Diane L.; Stubbins, James F.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 10 p. 2984 - 2989
反应条件
1: 76 percent / H2 / 10percent Pd/C / ethanol / 24 h / 760 Torr / Ambient temperature 2: 1.) NaNO2, HCl, 2.) KI / 1.) H2O, 0 deg C, 2.) H2O, RT, 16 h 3: SOCl2 / toluene / 1 h / 110 °C 4: toluene / 2 h / 110 °C View Scheme
参考文献
Strijckmans; Hunter; Dolle; Coulon; Loc'h; Maziere
Journal of Labelled Compounds and Radiopharmaceuticals, 1996 , vol. 38, # 5 p. 471 - 481
反应条件
hydrogen; palladium on activated charcoal in ethanol
P=760 Torr; 24 h; Ambient temperature;
参考文献
Strijckmans; Hunter; Dolle; Coulon; Loc'h; Maziere
Journal of Labelled Compounds and Radiopharmaceuticals, 1996 , vol. 38, # 5 p. 471 - 481
反应条件
sulfuric acid; nitric acid
T=0 - 20°C; 3 h;
参考文献
Strijckmans; Hunter; Dolle; Coulon; Loc'h; Maziere
Journal of Labelled Compounds and Radiopharmaceuticals, 1996 , vol. 38, # 5 p. 471 - 481
反应条件
sulfuric acid
T=100°C; 2 h;
参考文献
Illig, Carl R.; Ballentine, Shelley K.; Chen, Jinsheng; DesJarlais, Renee Louise; Meegalla, Sanath K.; Wall, Mark; Wilson, Kenneth
Patent: US2007/249608 A1, 2007 ;
Location in patent: Page/Page column 33 ;
US 20070249608 A1
