2’,3’-异亚丙基三氮唑核苷合成路线 （共 8 条）
反应条件
ion exchanger Merck I (H+) in water; acetone Ambient temperature;
参考文献
Schmidt; Heermann
Chemische Berichte, 1981 , vol. 114, # 8 p. 2825 - 2833
参考文献
ICN Pharmaceuticals, Inc.
Patent: US4138547 A1, 1979 ;
反应条件
1: 1.) NaH / 1.) THF, 0 deg C, 15 min, 2.) a.) 0 deg C, 2 h, b.) RT, 4 h 2: 93 percent / 80percent acetic acid / 2 h / 100 °C View Scheme
参考文献
Kini, Ganesh D.; Henry, Elizabeth M.; Robins, Roland K.; Larson, Steven B.; Marr, J. Joseph; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 44 - 48
反应条件
1: orthoformic acid triethyl ester With toluene-4-sulfonic acid in acetone
T=20°C; 20 h;
2: 1-(β-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide in N,N-dimethyl-formamide; acetone
T=50°C; 20 h;
参考文献
NEW RIVER PHARMACEUTICALS INC.
Patent: WO2006/50421 A1, 2006 ;
Location in patent: Page/Page column 17 ;
反应条件
perchloric acid in acetone
T=0°C; 1.5 h;
参考文献
Kini, Ganesh D.; Henry, Elizabeth M.; Robins, Roland K.; Larson, Steven B.; Marr, J. Joseph; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 44 - 48
反应条件
1: acetone With toluene-4-sulfonic acid; orthoformic acid triethyl ester
T=20°C;
2: 1-(β-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide in N,N-dimethyl-formamide
T=50°C;
参考文献
Li, Zicheng; Chen, Shuhua; Jiang, Ning; Cui, Gang
Nucleosides, Nucleotides and Nucleic Acids, 2003 , vol. 22, # 4 p. 419 - 435
反应条件
ammonia in methanol
Ambient temperature;
参考文献
Schmidt; Heermann
Chemische Berichte, 1981 , vol. 114, # 8 p. 2825 - 2833
反应条件
1: 81 percent / toluene / 5 h / 100 °C
2: 86 percent / NH3 / methanol / Ambient temperature
View Scheme
参考文献
Schmidt; Heermann
Chemische Berichte, 1981 , vol. 114, # 8 p. 2825 - 2833
