1,4,7-三对甲苯磺酰基-1,4,7-三氮杂环壬烷合成路线 （共 21 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=30°C; 72 h;
参考文献
Chavez, F.; Sherry, A. D.
Journal of Organic Chemistry, 1989 , vol. 54, # 12 p. 2990 - 2992
反应条件
1: With potassium carbonate in water
T=90°C; 1 h;
2: With sodium hydroxide; tetra(n-butyl)ammonium hydroxide; ethylene dibromide in water; xylene
T=90°C; 30 h; Further stages.;
参考文献
Niibayashi, Shota; Hayakawa, Hitoshi; Jin, Ren-Hua; Nagashima, Hideo
Chemical Communications, 2007 , # 18 p. 1855 - 1857
反应条件
1: N1-(2-Amino-ethyl)-ethane-1,2-diamine; p-toluenesulfonyl chloride With potassium carbonate in water
T=90°C; 1 h;
2: ethylene dibromide With tetra(n-butyl)ammonium hydroxide; sodium hydroxide in water; xylene
T=90°C; 30 h;
参考文献
Kyushu University, National University Corporation; Dainippon Ink and Chemicals, Inc.
Patent: US7674866 B2, 2010 ;
Location in patent: Page/Page column 16-17 ;
反应条件
1: 1,4-bis-(p-toluenesulfonyl)-1,4-diazabutane With lithium hydride in N,N-dimethyl-formamide
T=70°C; 2 h;
2: 4-methyl-N,N-bis[2-[[(4-methylphenyl)sulfonyl]oxy]ethyl]benzenesulfonamide in N,N-dimethyl-formamide
T=50°C; 120 h; Further stages.;
参考文献
Stones, Graham; Tripoli, Regis; McDavid, Colin L.; Roux-Duplgtre, Kewin; Kennedy, Alan R.; Sherrington, David C.; Gibson, Colin L.
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 2 p. 374 - 384
反应条件
potassium carbonate in acetonitrile
Cyclization; 240 h; Heating;
参考文献
Pulacchini, Sonia; Watkinson, Michael
Tetrahedron Letters, 1999 , vol. 40, # 52 p. 9363 - 9365
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
Iwata, Masaaki; Kuzuhara, Hiroyoshi
Journal of the Chemical Society, Chemical Communications, 1985 , # 13 p. 918 - 919
反应条件
in N,N-dimethyl-formamide
T=50°C;
参考文献
Iwata, Masaaki; Kuzuhara, Hiroyoshi
Chemistry Letters, 1986 , p. 369 - 372
反应条件
sodium hydroxide
1.) water; Yield given. Multistep reaction;
参考文献
Erhardt,J.M.; Grover,E.R.; Wuest,J.D.
Journal of the American Chemical Society, 1980 , vol. 102, p. 6365
反应条件
1: 94 percent / K2CO3 / dimethylformamide / Heating
2: 88 percent / Et3N; DMAP / CH2Cl2 / 24 h / 20 °C
3: 97 percent / K2CO3 / acetonitrile / 144 h / Heating
View Scheme
参考文献
Pulacchini, Sonia; Watkinson, Michael
European Journal of Organic Chemistry, 2001 , # 22 p. 4233 - 4238
反应条件
1: 88 percent / Et3N; DMAP / CH2Cl2 / 24 h / 20 °C
2: 97 percent / K2CO3 / acetonitrile / 144 h / Heating
View Scheme
参考文献
Pulacchini, Sonia; Watkinson, Michael
European Journal of Organic Chemistry, 2001 , # 22 p. 4233 - 4238
