(4-甲氧基苯基)(苯基)甲基胺合成路线 （共 7 条）
反应条件
hydrogenchloride in tetrahydrofuran; water
T=0 - 20°C; Inert atmosphere;
参考文献
Li, Minyan; Yuecel, Baris; Adrio, Javier; Bellomo, Ana; Walsh, Patrick J.
Chemical Science, 2014 , vol. 5, # 6 p. 2383 - 2391
反应条件
1: 1.) Mg / 1.) THF, 40-45 deg C, 2.) THF, 20-25 deg C, 2 h
2: HCl, H2O / tetrahydrofuran / 192 h / Ambient temperature
View Scheme
参考文献
Zwierzak, Andrzej; Napieraj, Anna
Synthesis, 1999 , # 6 p. 930 - 934
反应条件
1: 1.) Mg / 1.) THF, 40-45 deg C, 2.) THF, 20-25 deg C, 2 h
2: HCl, H2O / tetrahydrofuran / 192 h / Ambient temperature
View Scheme
参考文献
Zwierzak, Andrzej; Napieraj, Anna
Synthesis, 1999 , # 6 p. 930 - 934
反应条件
1: tetrahydrofuran / 12 h / 50 °C / |Inert atmosphere
2: palladium diacetate; Nixantphos; sodium hexamethyldisilazane / 3 h / 24 °C / |Inert atmosphere
3: hydrogenchloride / tetrahydrofuran; water / 0 - 20 °C / |Inert atmosphere
View Scheme
参考文献
Li, Minyan; Yuecel, Baris; Adrio, Javier; Bellomo, Ana; Walsh, Patrick J.
Chemical Science, 2014 , vol. 5, # 6 p. 2383 - 2391
反应条件
1: palladium diacetate; Nixantphos; sodium hexamethyldisilazane / 3 h / 24 °C / |Inert atmosphere
2: hydrogenchloride / tetrahydrofuran; water / 0 - 20 °C / |Inert atmosphere
View Scheme
参考文献
Li, Minyan; Yuecel, Baris; Adrio, Javier; Bellomo, Ana; Walsh, Patrick J.
Chemical Science, 2014 , vol. 5, # 6 p. 2383 - 2391
反应条件
1: palladium diacetate; Nixantphos; sodium hexamethyldisilazane / 3 h / 24 °C / |Inert atmosphere
2: hydrogenchloride / tetrahydrofuran; water / 0 - 20 °C / |Inert atmosphere
View Scheme
参考文献
Li, Minyan; Yuecel, Baris; Adrio, Javier; Bellomo, Ana; Walsh, Patrick J.
Chemical Science, 2014 , vol. 5, # 6 p. 2383 - 2391
反应条件
hydrogenchloride; formic acid; ammonia; magnesium chloride
1) reflux 2) MeOH, reflux; Multistep reaction;
参考文献
Estiu; Cachau; Castro; Bruno Blanch
Farmaco, 1990 , vol. 45, # 7-8 p. 889 - 900
