(7CI,8CI,9CI)-3-甲基-噻唑并[3,2-a]苯并咪唑合成路线 （共 32 条）
反应条件
triethylamine in acetonitrile
T=20°C; 0.25 h;
参考文献
Doukara, Abdallah Larbi; Mehdid, Mohammed Amine; Djafri, Ayada; Andreoli, Federico; Vanthuyne, Nicolas; Roussel, Christian
Tetrahedron, 2010 , vol. 66, # 10 p. 1852 - 1858
反应条件
triethylamine in acetonitrile
T=20°C; 0.25 h;
参考文献
Doukara, Abdallah Larbi; Mehdid, Mohammed Amine; Djafri, Ayada; Andreoli, Federico; Vanthuyne, Nicolas; Roussel, Christian
Tetrahedron, 2010 , vol. 66, # 10 p. 1852 - 1858
反应条件
sodium methylate in methanol
T=60°C; 3 h;
参考文献
Yaroshenko; Nakhmanovich; Larina; Elokhina; Amosova
Chemistry of Heterocyclic Compounds, 2008 , vol. 44, # 9 p. 1129 - 1134
反应条件
potassium hydroxide in ethanol; sulfuric acid; ethyl acetate
参考文献
Yamanouchi Pharmaceutical Co., Ltd.
Patent: US6642264 B1, 2003 ;
反应条件
sodium methylate in methanol
T=60°C; 3 h;
参考文献
Yaroshenko; Nakhmanovich; Larina; Elokhina; Amosova
Chemistry of Heterocyclic Compounds, 2008 , vol. 44, # 9 p. 1129 - 1134
反应条件
potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in dimethyl sulfoxide
3 h; Heating;
参考文献
Popov, I. I.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1995 , vol. 31, # 4 p. 500 - 503
Khimiya Geterotsiklicheskikh Soedinenii, 1995 , # 4 p. 567 - 570
反应条件
triethylamine in N,N-dimethyl-formamide
T=20°C; 0.333333 h;
参考文献
Boeini, Hassan Zali
Helvetica Chimica Acta, 2009 , vol. 92, # 7 p. 1268 - 1272
反应条件
sodium methylate in methanol
24 h;
参考文献
Yaroshenko; Nakhmanovich; Larina; Elokhina; Amosova
Chemistry of Heterocyclic Compounds, 2008 , vol. 44, # 9 p. 1129 - 1134
反应条件
1: acetyl chloride; 2-mercaptobenzoimidazole With potassium hydroxide in ethanol
T=20°C; 1 h; Heating / reflux;
2: sulfuric acid T=20°C; 6 h;
参考文献
YAMANOUCHI PHARMACEUTICAL CO. LTD.
Patent: EP1167369 A1, 2002 ;
Location in patent: Page 20 ;
EP 1167369 A1
反应条件
sulfuric acid; mercury(II) diacetate in acetic acid
Heating;
参考文献
Balasubramanian,K.K.; Nagarajan,R.
Synthesis, 1976 , p. 189
