4-环氧乙烷-2-基苯甲腈合成路线 （共 8 条）
反应条件
hexafluoroisopropyl alcohol; benzoic acid fluoride; C72H98Co2N4O8; DBN; 2,2,2-trimethylacetic acid in decane; tert-butyl methyl ether T=24°C; 2 h; optical yield given as percent eeenantioselective reaction;
参考文献
Kalow, Julia A.; Doyle, Abigail G.
Journal of the American Chemical Society, 2011 , vol. 133, # 40 p. 16001 - 16012
反应条件
carbon monoxide in tetrahydrofuran; water T=110°C; P=6840.46 Torr; 12 h; Autoclave; chemoselective reaction;
参考文献
Mikami, Yusuke; Noujima, Akifumi; Mitsudome, Takato; Mizugaki, Tomoo; Jitsukawa, Koichiro; Kaneda, Kiyotomi
Tetrahedron Letters, 2010 , vol. 51, # 41 p. 5466 - 5468
反应条件
water in ethanol T=27°C; 0.75 h; biohydrolysis using Aspergillus niger; pH 8; Yield given. Yields of byproduct given;
参考文献
Journal of Organic Chemistry, , vol. 61, # 21 p. 7402 - 7407
反应条件
sodium tetrahydroborate; potassium carbonate in tetrahydrofuran; acetonitrile
参考文献
AstraZeneca AB
Patent: US6291475 B1, 2001 ;
US 6291475 B1
参考文献
VIFOR (INTERNATIONAL) AG
Patent: US2012/214798 A1, 2012 ;
反应条件
1: With manganese sulphate monohydrate; (1R,2R)-N1,N1,N2-tris(pyridin-2-ylmethyl)cyclohexane-1,2-diamine in acetonitrile
T=20°C; 0.25 h;
2: With dihydrogen peroxide in water; acetone; acetonitrile
4 h; Catalytic behaviorKinetics; Reagent/catalyst;
参考文献
Ilyashenko, Gennadiy; De Faveri, Giorgio; Follier, Thomas; Al-Safadi, Rawan; Motevalli, Majid; Watkinson, Michael
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 7 p. 1124 - 1134
反应条件
1: trimethyl-oxo-sulfonium iodide With sodium hydride in dimethyl sulfoxide
Dehydroiodination;
2: [4-cyanophenyl]methanone in dimethyl sulfoxide
T=20 - 60°C; Cycloaddition; 2.8 h;
参考文献
Iwasaki, Takeshi; Kihara, Nobuhiro; Endo, Takeshi
Bulletin of the Chemical Society of Japan, 2000 , vol. 73, # 3 p. 713 - 719
反应条件
potassium carbonate in methanol
参考文献
Kalow, Julia A.; Doyle, Abigail G.
Journal of the American Chemical Society, 2011 , vol. 133, # 40 p. 16001 - 16012
