4-(2H-四唑-2-基)苯胺合成路线 （共 4 条）
反应条件
sulfuric acid; sodium nitrite in water
T=0 - 120°C; 1.5 h;
参考文献
MERCK and CO., INC.
Patent: WO2009/129036 A1, 2009 ;
Location in patent: Page/Page column 74-75 ;
WO 2009/129036 A1
反应条件
hydrogen; palladium 10 on activated carbon in ethanol; ethyl acetate
2 h; Inert atmosphere;
参考文献
MERCK and CO., INC.
Patent: WO2009/129036 A1, 2009 ;
Location in patent: Page/Page column 74 ;
WO 2009/129036 A1
反应条件
1: With potassium carbonate in N,N-dimethyl-formamide
T=80°C;
2: With platinum(IV) oxide; hydrogen in tetrahydrofuran
T=20°C;
参考文献
MERCK CANADA INC.; BOYD, Michael John; CHIASSON, Jean-François; CRANE, Sheldon; GIROUX, André
Patent: WO2013/59928 A1, 2013 ;
Location in patent: Page/Page column 33 ;
反应条件
1: With potassium carbonate in N,N-dimethyl-formamide
T=70 - 75°C; 10 h;
2: With iron(III) chloride; carbon; hydrazine hydrate in tetrahydrofuran; methanol
T=50°C; 10 h;
参考文献
Kitazaki, Tomoyuki; Ichikawa, Takashi; Tasaka, Akihiro; Hosono, Hiroshi; Matsushita, Yoshihiro; Hayashi, Ryogo; Okonogi, Kenji; Itoh, Katsumi
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 12 p. 1935 - 1946
