1-溴-2-(甲氧基甲基)苯合成路线 （共 24 条）
反应条件
1: pyridine
2: aq.-ethanolic NaOH
3: LiAlH4; diethyl ether
View Scheme
参考文献
Mann; Stewart
Journal of the Chemical Society, 1954 , p. 2819,2824
反应条件
magnesium in tetrahydrofuran
T=0 - 20°C; 18 h;
参考文献
Soma, Takahiro; Shimizu, Toshio; Hirabayashi, Kazunori; Kamigata, Nobumasa
Heteroatom Chemistry, 2007 , vol. 18, # 3 p. 301 - 311
反应条件
1: 1.) Mg, I2, 2.) CuBr / 1.) THF, 12 h, reflux, 2.) THF, HMPA, 24 h, reflux
2: 69 percent / 48percent aq. HBr / 24 h / Heating
View Scheme
参考文献
Yamato, Takehiko; Sakaue, Naozumi; Furusawa, Takashi; Tashiro, Masahi; Prakash, G.K.Surya; Olah, George A.
Journal of Chemical Research, Miniprint, 1991 , # 9 p. 2414 - 2438
反应条件
1: 1) BuLi / 1) hexane, THF, -100 deg C, 20 min., 2) a) -100 deg C, 2 h, b) 25 deg C, 30 min.
2: t-BuOK / dimethylformamide / 19 h / -10 °C
View Scheme
参考文献
Mueller, Paul; Bernardinelli, Gerald; Jacquier, Yvan
Helvetica Chimica Acta, 1992 , vol. 75, # 6 p. 1995 - 2008
