3-(三甲基硅基)丙炔醇合成路线 （共 67 条）
反应条件
in tetrahydrofuran T=64 - 65°C; 9 h;
参考文献
Novokshonov; Medvedeva; Mareev
Russian Journal of Organic Chemistry, 2001 , vol. 37, # 11 p. 1549 - 1552
反应条件
Yield given. Multistep reaction;
参考文献
Hwu; Furth
Journal of the American Chemical Society, 1989 , vol. 111, # 24 p. 8834 - 8841
反应条件
ethylmagnesium bromide 1.) Et2O, room temp., overnight, 2.) 0 deg C; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Denmark, S. E.; Jones, T. K.
Journal of Organic Chemistry, 1982 , vol. 47, # 23 p. 4595 - 4597
反应条件
in diethyl ether Heating;
参考文献
Cutting, Ian; Parsons, Philip J.
Tetrahedron Letters, 1983 , vol. 24, # 41 p. 4463 - 4464
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; n-butyllithium; Amberlyst 15 1) hexane, THF, room temperature, overnight; 2) methanol, 40 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Crousse, B.; Pichon, O.; Soulie, J.
Bulletin de la Societe Chimique de France, 1993 , vol. 130, # 2 p. 154 - 159
反应条件
ethylmagnesium bromide 1.) THF, reflux, 1 h, 2.) THF, reflux, 3 h; Yield given. Multistep reaction;
参考文献
Novokshonov; Medvedeva; Demina; Sherstyannikova; Voronkov
Russian Journal of Organic Chemistry, 1996 , vol. 32, # 12 p. 1770 - 1773
参考文献
Wensbo, David; Eriksson, Ann; Jeschke, Torsten; Annby, Ulf; Gronowitz, Salo; Cohen, Louis A.
Tetrahedron Letters, 1993 , vol. 34, # 17 p. 2823 - 2826
反应条件
in tetrahydrofuran 9 h; Heatingother bromomagnesium derivatives of alkynyl trimethylsilyl ethers, presence of LiClO4, LiBr, Me4NBr, HgCl2 or CoCl2, other solvents: Et2O, Et2O/THF, Et2O/CH2Cl2, HMPA/C6H6, CH2Cl2, iPr2O, MeOCH2CH2OMe, other reaction time, various reactants ratio; Mechanism;
参考文献
Novokshonov; Medvedeva; Demina; Sherstyannikova; Voronkov
Russian Journal of Organic Chemistry, 1996 , vol. 32, # 12 p. 1770 - 1773
反应条件
lithium aluminium tetrahydride in diethyl ether
参考文献
Wilson, Stephen R.; Zucker, Paul A.
Journal of Organic Chemistry, 1988 , vol. 53, # 20 p. 4682 - 4693
反应条件
sulfuric acid in hexane; ethyl acetate; toluene
参考文献
Merrell Dow Pharmaceuticals, Inc.
Patent: US5252587 A1, 1993 ;
