2-甲基-4-溴-5-氟苯胺合成路线 （共 7 条）
反应条件
hydrogenchloride; tin(ll) chloride
参考文献
Dabrowski, Marek; Kubicka, Joanna; Lulinski, Sergiusz; Serwatowski, Janusz
Tetrahedron, 2005 , vol. 61, # 27 p. 6590 - 6595
反应条件
1: HNO3; H2SO4 2: 15.5 g / SnCl2; HCl View Scheme
参考文献
Dabrowski, Marek; Kubicka, Joanna; Lulinski, Sergiusz; Serwatowski, Janusz
Tetrahedron, 2005 , vol. 61, # 27 p. 6590 - 6595
反应条件
1.1: chloroform / 20 °C / Cooling with ice 1.2: 16 h / 75 °C 2.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 36 h / 120 - 130 °C / Inert atmosphere View Scheme
参考文献
GLAXO WELLCOME HOUSE
Patent: US2012/283297 A1, 2012 ;
反应条件
1: With hydrogenchloride; sodium nitrite in water
T=0 - 5°C;
2: With potassium iodide in water
参考文献
Dabrowski, Marek; Kubicka, Joanna; Lulinski, Sergiusz; Serwatowski, Janusz
Tetrahedron, 2005 , vol. 61, # 27 p. 6590 - 6595
反应条件
1.1: chloroform / 20 °C / Cooling with ice
1.2: 16 h / 75 °C
2.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 36 h / 120 - 130 °C / Inert atmosphere
View Scheme
参考文献
GLAXO WELLCOME HOUSE
Patent: US2012/283297 A1, 2012 ;
反应条件
1: in chloroform
T=20°C; Cooling with ice;
2: With tert.-butylnitrite; potassium acetate; 18-crown-6 ether in chloroform
T=75°C; 16 h;
3: With sodium hydrogencarbonate in dichloromethane; chloroform; water
参考文献
GLAXO GROUP LIMITED; BAILEY, James; KING, Nigel Paul; LIN, Xichen; REN, Feng; TAN, Kheng-Chuan; MAK, Sing Yeung
Patent: WO2011/72488 A1, 2011 ;
Location in patent: Page/Page column 17; 38-39 ;
WO 2011/072488 A1
反应条件
potassium acetate; 18-crown-6 ether in chloroform
T=20 - 75°C; 16 h; Cooling with ice;
参考文献
GLAXO WELLCOME HOUSE
Patent: US2012/283297 A1, 2012 ;
Location in patent: Page/Page column 22 ;
