1-乙基-5-氧代吡咯烷-3-羧酸合成路线 （共 2 条）
反应条件
1: With water; sodium hydroxide in tetrahydrofuran; methanol
T=0 - 20°C; 0.5 h;
2: in tetrahydrofuran; methanol
T=20°C; 0.5 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP2530078 A1, 2012 ;
Location in patent: Page/Page column 68 ;
反应条件
1.1: toluene; methanol / 22 h / 100 °C / Sealed tube
2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 0.5 h / 0 - 20 °C
2.2: ion exchange resin CG50 / 0.5 h / 20 °C
View Scheme
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP2530078 A1, 2012 ;
