(2-氨基苯基)-吡咯烷-1-甲酮合成路线 （共 4 条）
反应条件
1: anthranilic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran
T=25°C; 1 h;
2: pyrrolidine in tetrahydrofuran
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; CHENG, Liang; LIU, Xijie; HU, Yuandong; XU, Xinhe; LIU, Zhihua; ZHANG, Lipeng; WU, Wei; WANG, Shulong; SHEN, Yu; LI, Gen; WANG, Yin; ZHAO, Sheng; LI, Chonglong; TANG, Jia; YU, Honghao
Patent: WO2012/92880 A1, 2012 ;
Location in patent: Page/Page column 63 ;
WO 2012/092880 A1
反应条件
4-(N,N-dimethlyamino)pyridine in N,N-dimethyl-formamide
2 h; Ambient temperature;
参考文献
Venuti, Michael C.
Synthesis, 1982 , # 4 p. 266 - 268
反应条件
copper acetylacetonate; sodium tetrahydroborate in ethanol
2 h; Ambient temperature;
参考文献
Murphy, John A.; Roome, Stephen J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 11 p. 1349 - 1358
反应条件
1: 88.5 percent / tetrahydrofuran / 0.5 h
2: 94 percent / copper acetylacetonate, NaBH4 / ethanol / 2 h / Ambient temperature
View Scheme
参考文献
Murphy, John A.; Roome, Stephen J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 11 p. 1349 - 1358
