8-羟基-3,4-二氢-2-喹啉酮合成路线 （共 7 条）
反应条件
AlCl3, aluminium chloride T=130°C; 5 h;
参考文献
ASTRAZENECA AB
Patent: WO2005/54249 A1, 2005 ;
Location in patent: Page/Page column 21 ;
WO 2005/054249 A1
反应条件
1,4-dioxane; palladium T=55°C; Hydrogenation;
参考文献
Cavallito; Haskell
Journal of the American Chemical Society, 1944 , vol. 66, p. 1166,1168
反应条件
aluminium trichloride T=220°C;
参考文献
Pai; Samel
Asian Journal of Chemistry, 2011 , vol. 23, # 4 p. 1655 - 1660
反应条件
2: aluminium chloride / 220 °C View Scheme
参考文献
Pai; Samel
Asian Journal of Chemistry, 2011 , vol. 23, # 4 p. 1655 - 1660
反应条件
water; hydrogen bromide
参考文献
Sidhu et al.
Justus Liebigs Annalen der Chemie, 1959 , vol. 627, p. 224,225
反应条件
1: palladium/barium sulfate; ethanol / Hydrogenation 2: hydrobromic acid; water View Scheme
参考文献
Sidhu et al.
Justus Liebigs Annalen der Chemie, 1959 , vol. 627, p. 224,225
反应条件
potassium carbonate; acetone
参考文献
Loudon; Ogg
Journal of the Chemical Society, 1955 , p. 739,743
