N-苄基-3-氧代哌啶-4-羧酸乙酯盐酸盐合成路线 （共 21 条）
反应条件
1: With sodium ethanolate in toluene T=20 - 85°C; 3.5 h; Large scale; 2: With hydrogenchloride in water; toluene Large scale;
参考文献
Scalone, Michelangelo; Waldmeier, Pius
Organic Process Research and Development, 2003 , vol. 7, # 3 p. 418 - 425
反应条件
hydrogenchloride in ethanol T=22°C; 0.5 h; Inert atmosphereLarge scale;
参考文献
Connolly, Terrence J.; Matchett, Michael; Sarma, Keshab
Organic Process Research and Development, 2005 , vol. 9, # 1 p. 80 - 87
反应条件
1.1: triethylamine / 1,4-dioxane / 22 h / |Reflux; |Large scale 2.1: sodium ethanolate / toluene / 3.5 h / 20 - 85 °C / |Large scale 2.2: |Large scale View Scheme
参考文献
Scalone, Michelangelo; Waldmeier, Pius
Organic Process Research and Development, 2003 , vol. 7, # 3 p. 418 - 425
反应条件
1.1: triethylamine / 1,4-dioxane / 22 h / |Reflux; |Large scale 2.1: sodium ethanolate / toluene / 3.5 h / 20 - 85 °C / |Large scale 2.2: |Large scale View Scheme
参考文献
Scalone, Michelangelo; Waldmeier, Pius
Organic Process Research and Development, 2003 , vol. 7, # 3 p. 418 - 425
反应条件
sodium hydrogencarbonate in diethyl ether; water 1 h;
参考文献
PFIZER INC.
Patent: WO2008/120093 A1, 2008 ;
Location in patent: Page/Page column 74-75 ;
反应条件
1: With sodium ethanolate in ethanol T=60°C; 2: With trichlorophosphate T=90°C; 5 h;
参考文献
Lee, Chih-Hung; Brown, Brian S.; Keddy, Ryan G.; Perner, Richard J.; Koenig, John R.
Patent: US2006/128710 A1, 2006 ;
Location in patent: Page/Page column 11 ;
反应条件
hydrogen; triethylamine; palladium(II) hydroxide/carbon in ethanol P=3102.97 Torr; 5 h;
参考文献
TARGACEPT, INC.
Patent: WO2008/112734 A1, 2008 ;
Location in patent: Page/Page column 72 ;
WO 2008/112734 A1
反应条件
1: ethanol / 16 h / 120 °C / |Reflux 2: trichlorophosphate / 3 h / 100 °C View Scheme
参考文献
JANSSEN RandD IRELAND; MC GOWAN, David Craig; RABOISSON, Pierre Jean-Marie Bernard; JONCKERS, Tim Hugo Maria; DAOUBI KHAMLICHI, Mourad
Patent: WO2013/117615 A1, 2013 ;
反应条件
palladium 10 on activated carbon; hydrogen; triethylamine in methanol 4 h; Autoclave;
参考文献
Hao, Bao-Yu; Liu, Jin-Qiang; Zhang, Wei-Han; Chen, Xin-Zhi
Synthesis, 2011 , # 8 art. no. F14011SS, p. 1208 - 1212
反应条件
1: H2 / Pd/C / ethanol; H2O / 20 h / 2585.74 Torr 2: 2.2 g / NaHCO3; NaCl / CHCl3; H2O / 8 h / 70 °C View Scheme
参考文献
Ueda, T.; Nagatsuka, S.; Irie, T.; Fukushi, K.; Tanada, S.; Takaoku, K.; Yomoda, I.; Shirashi, H.
Journal of Labelled Compounds and Radiopharmaceuticals, 2001 , vol. 44, p. S254 - S256
