2,3-二甲基-5-亚甲基-2-环戊烯-1-酮合成路线 （共 64 条）
反应条件
1: 78 percent / 50percent aq. NaOH, benzyltrimethylammonium chloride / from 0 degC to roomtemp.
2: 95 percent / neat (no solvent) / 110 °C / 0.02 - 0.05 Torr
View Scheme
参考文献
Pohmakotr, Manat; Chancharunee, Sirirat
Tetrahedron Letters, 1984 , vol. 25, # 37 p. 4141 - 4144
反应条件
1: 73 percent / LDA / tetrahydrofuran / -78 degC, 1 h., then 0 degC, 1 h.
2: 78 percent / 50percent aq. NaOH, benzyltrimethylammonium chloride / from 0 degC to roomtemp.
3: 95 percent / neat (no solvent) / 110 °C / 0.02 - 0.05 Torr
View Scheme
参考文献
Pohmakotr, Manat; Chancharunee, Sirirat
Tetrahedron Letters, 1984 , vol. 25, # 37 p. 4141 - 4144
反应条件
1: 79 percent / NaOH / ethanol
2: 49 percent / LDA / tetrahydrofuran / -78 °C
3: 82 percent / DCC ,Cu2I2
View Scheme
参考文献
Mikolajczyk; Grzejszczak; Lyzwa
Tetrahedron Letters, 1982 , vol. 23, # 21 p. 2237 - 2240
反应条件
1: 80 percent / H2O ,TsOH
2: 79 percent / NaOH / ethanol
3: 49 percent / LDA / tetrahydrofuran / -78 °C
4: 82 percent / DCC ,Cu2I2
View Scheme
参考文献
Mikolajczyk; Grzejszczak; Lyzwa
Tetrahedron Letters, 1982 , vol. 23, # 21 p. 2237 - 2240
反应条件
1: 91 percent / 0.2 N HCl / 5 h / Heating
2: 39 percent / Pb(OAc)4, Cu(OAc)2*H2O, pyridine / benzene / 2 h / 80 °C
View Scheme
参考文献
Camps; Coll; Moreto; Torras
Tetrahedron Letters, 1985 , vol. 26, # 51 p. 6397 - 6398
反应条件
T=600 - 630°C; P=15 Torr;
参考文献
Koller, Manuel; Karpf, Martin; Dreiding, Andre S.
Helvetica Chimica Acta, 1986 , vol. 69, p. 560 - 579
反应条件
T=600 - 630°C; P=15 Torr;
参考文献
Koller, Manuel; Karpf, Martin; Dreiding, Andre S.
Helvetica Chimica Acta, 1986 , vol. 69, p. 560 - 579
反应条件
1: 79 percent / KHCO3 / ethanol; H2O / 48 h
2: 40 percent / aq. NaPH / tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Newton, Roger F.; Reynolds, Derek P.
Synthetic Communications, 1981 , vol. 11, # 7 p. 527 - 532
反应条件
1: 40 percent / aq. NaPH / tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Newton, Roger F.; Reynolds, Derek P.
Synthetic Communications, 1981 , vol. 11, # 7 p. 527 - 532
反应条件
1.1: 71 percent / titanium(IV) isopropoxide; isopropylmagnesium bromide / diethyl ether
2.1: 50 percent / oxalyl chloride; dimethyl sulfoxide; triethylamine / CH2Cl2 / -60 - 0 °C
3.1: pyridinium bromide perbromide / diethyl ether / 2 h / 20 °C
3.2: triethylanine / diethyl ether / 16 h / 20 °C
3.3: 47 percent / piperidine / diethyl ether / 24 h / 20 °C
4.1: 75 percent / NaOH / ethanol / 5 h / 20 °C
5.1: NaIO4 / acetone; H2O / 35 h
6.1: 60 percent / NaHCO3 / hexane; diethyl ether / 10 h / Heating
View Scheme
参考文献
Shevchuk; Kulinkovich
Russian Journal of Organic Chemistry, 2000 , vol. 36, # 8 p. 1124 - 1126
