2,3-二甲基-5-亚甲基-2-环戊烯-1-酮合成路线 （共 64 条）
反应条件
1.1: 50 percent / oxalyl chloride; dimethyl sulfoxide; triethylamine / CH2Cl2 / -60 - 0 °C
2.1: pyridinium bromide perbromide / diethyl ether / 2 h / 20 °C
2.2: triethylanine / diethyl ether / 16 h / 20 °C
2.3: 47 percent / piperidine / diethyl ether / 24 h / 20 °C
3.1: 75 percent / NaOH / ethanol / 5 h / 20 °C
4.1: NaIO4 / acetone; H2O / 35 h
5.1: 60 percent / NaHCO3 / hexane; diethyl ether / 10 h / Heating
View Scheme
参考文献
Shevchuk; Kulinkovich
Russian Journal of Organic Chemistry, 2000 , vol. 36, # 8 p. 1124 - 1126
反应条件
1.1: pyridinium bromide perbromide / diethyl ether / 2 h / 20 °C
1.2: triethylanine / diethyl ether / 16 h / 20 °C
1.3: 47 percent / piperidine / diethyl ether / 24 h / 20 °C
2.1: 75 percent / NaOH / ethanol / 5 h / 20 °C
3.1: NaIO4 / acetone; H2O / 35 h
4.1: 60 percent / NaHCO3 / hexane; diethyl ether / 10 h / Heating
View Scheme
参考文献
Shevchuk; Kulinkovich
Russian Journal of Organic Chemistry, 2000 , vol. 36, # 8 p. 1124 - 1126
反应条件
1: NaIO4 / acetone; H2O / 35 h
2: 60 percent / NaHCO3 / hexane; diethyl ether / 10 h / Heating
View Scheme
参考文献
Shevchuk; Kulinkovich
Russian Journal of Organic Chemistry, 2000 , vol. 36, # 8 p. 1124 - 1126
反应条件
1: 75 percent / NaOH / ethanol / 5 h / 20 °C
2: NaIO4 / acetone; H2O / 35 h
3: 60 percent / NaHCO3 / hexane; diethyl ether / 10 h / Heating
View Scheme
参考文献
Shevchuk; Kulinkovich
Russian Journal of Organic Chemistry, 2000 , vol. 36, # 8 p. 1124 - 1126
反应条件
1: methanol / 20 h / Ambient temperature
2: 5percent aq, NaHCO3 / CH2Cl2 / 2 h / Ambient temperature
View Scheme
参考文献
Tonari Machiya Ichimoto; Ueda
Agricultural and Biological Chemistry, 1981 , vol. 45, # 1 p. 295 - 300
反应条件
1: 93 percent / m-chloroperbenzoic acid / CH2Cl2 / 1 h / 0 °C
2: 44 percent / aq. NaOH / dimethylsulfoxide / 1 h / temp.: 0 deg C to room temp.
View Scheme
参考文献
Takahashi; Kosugi; Uda
Journal of the Chemical Society - Series Chemical Communications, 1982 , vol. No. 9, p. 496 - 497
反应条件
1: 79 percent / diethyl ether / 0.05 h / -50 °C
2: 93 percent / m-chloroperbenzoic acid / CH2Cl2 / 1 h / 0 °C
3: 44 percent / aq. NaOH / dimethylsulfoxide / 1 h / temp.: 0 deg C to room temp.
View Scheme
参考文献
Takahashi; Kosugi; Uda
Journal of the Chemical Society - Series Chemical Communications, 1982 , vol. No. 9, p. 496 - 497
反应条件
1: toluene; tetrahydrofuran / 0.5 h / -78 °C
2: sodium hydroxide / H2O; ethanol / 16 h / Heating
3: 31 percent / lead tetraacetate, cupric acetate monohydrate, pyridine / benzene / 0.42 h / Heating
View Scheme
参考文献
Strunz; Lal
Canadian Journal of Chemistry, 1982 , vol. 60, # 20 p. 2528 - 2530
反应条件
1: 53 percent / pyridine / 4.5 h / Heating
2: toluene; tetrahydrofuran / 0.5 h / -78 °C
3: sodium hydroxide / H2O; ethanol / 16 h / Heating
4: 31 percent / lead tetraacetate, cupric acetate monohydrate, pyridine / benzene / 0.42 h / Heating
View Scheme
参考文献
Strunz; Lal
Canadian Journal of Chemistry, 1982 , vol. 60, # 20 p. 2528 - 2530
反应条件
1: Ca(OCl)2, AcOH / CH2Cl2
2: 1.) lithium diisopropylamide (LDA) / 1.) THF, from -70 deg C to 0 deg C
3: 1.) lithium diisopropylamide (LDA) / 1.) THF, from -70 deg C to RT
4: 30percent H2O2 / acetone / 0 °C
View Scheme
参考文献
Mathew, Jacob
Journal of the Chemical Society, Chemical Communications, 1990 , # 18 p. 1264 - 1266
