(3-溴-4,5-二甲氧基苯基)甲醇合成路线 （共 10 条）
反应条件
[Ir(μ-Cl)(cyclooctene)2]2; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; lithium chloride in water; 1,3,5-trimethyl-benzene T=170°C; 24 h; Schlenk techniqueInert atmosphere;
参考文献
Olsen, Esben P. K.; Madsen, Robert
Chemistry - A European Journal, 2012 , vol. 18, # 50 p. 16023 - 16029
反应条件
1: 59 percent / p-toluenesulfonic acid monohydrate / CH2Cl2 / 2 h / 20 °C
2: 17 percent / K2CO3; CuO; pyridine / 6 h / Heating
3: 36 percent / H2 / Pd/C / ethyl acetate / 20 °C / atmospheric pressure
4: 11 mg / BBr3 / CH2Cl2 / 1.5 h / 20 °C
View Scheme
参考文献
Takenaka, Yukiko; Tanahashi, Takao; Nagakura, Naotaka; Hamada, Nobuo
Chemical and pharmaceutical bulletin, 2003 , vol. 51, # 7 p. 794 - 797
反应条件
1: methanol. KOH; copper-powder / Erhitzen des Reaktionsprodukts mit wss. NaOH
2: SOCl2 / Erwaermen des Reaktionsprodukts mit NaCN in wss. Aceton
View Scheme
参考文献
Tolkatschew et al.
Zhurnal Obshchei Khimii, 1959 , vol. 29, p. 1627,1630; engl. Ausg. S. 1601, 1604
反应条件
sodium tetrahydroborate in methanol
T=0°C;
参考文献
Barrett, Tim N.; Braddock, D. Christopher; Monta, Anna; Webb, Michael R.; White, Andrew J.P.
Journal of Natural Products, 2011 , vol. 74, # 9 p. 1980 - 1984
反应条件
sodium hydride in tetrahydrofuran
T=0°C; Reflux;
参考文献
Zhao, Xue Zhi; Maddali, Kasthuraiah; Smith, Steven J.; Metifiot, Mathieu; Johnson, Barry C.; Marchand, Christophe; Hughes, Stephen H.; Pommier, Yves; Burke Jr., Terrence R.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 24 p. 7309 - 7313
反应条件
1: 3-methoxy-4-hydroxy-5-bromo-benzaldehyde With potassium carbonate in dimethyl amine
T=0°C; 0.25 h;
2: methyl iodide in dimethyl amine
参考文献
Olsen, Esben P. K.; Madsen, Robert
Chemistry - A European Journal, 2012 , vol. 18, # 50 p. 16023 - 16029
反应条件
boron trifluoride diethyl etherate; sodium cyanoborohydride in tetrahydrofuran
10 h; Heating;
参考文献
Srikrishna; Satyanarayana
Tetrahedron, 2006 , vol. 62, # 12 p. 2892 - 2900
反应条件
1: 89 percent / sodium hydroxide; Adogen 464(R) / CH2Cl2 / 15 h / 20 °C
2: sodium borohydride / tetrahydrofuran; methanol / 2 h
View Scheme
参考文献
Wang, You-Chu; Georghiou, Paris E.
Organic Letters, 2002 , vol. 4, # 16 p. 2675 - 2678
反应条件
1: 94 percent / bromine; acetic acid / 1 h / 20 °C
2: 89 percent / sodium hydroxide; Adogen 464(R) / CH2Cl2 / 15 h / 20 °C
3: sodium borohydride / tetrahydrofuran; methanol / 2 h
View Scheme
参考文献
Wang, You-Chu; Georghiou, Paris E.
Organic Letters, 2002 , vol. 4, # 16 p. 2675 - 2678
参考文献
Tolkatschew et al.
Zhurnal Obshchei Khimii, 1959 , vol. 29, p. 1627,1630; engl. Ausg. S. 1601, 1604
