(R)-2-氨基丁基-3-烯酸合成路线 （共 7 条）
反应条件
hydrogenchloride
4.5 h; Heating;
参考文献
Elkins, Jonathan M.; Rutledge, Peter J.; Burzlaff, Nicolai I.; Clifton, Ian J.; Adlington, Robert M.; Roach, Peter L.; Baldwin, Jack E.
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 9 p. 1455 - 1460
反应条件
hydrogenchloride
1 h; Heating;
参考文献
Hallinan, Keith O.; Crout, David H. G.; Errington, William
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 24 p. 3537 - 3544
反应条件
1: With trimethylaluminum; zinc in tetrahydrofuran
T=20°C; 4 h;
2: With hydrogenchloride
1 h; Heating; Title compound not separated from byproducts;
参考文献
Rose, Nicholas G.W; Blaskovich, Mark A; Wong, Alex; Lajoie, Gilles A
Tetrahedron, 2001 , vol. 57, # 8 p. 1497 - 1507
反应条件
1: Methyltriphenylphosphonium bromide With potassium tert-butylate in diethyl ether
0.25 h; Heating;
2: Lajoie's serine aldehyde in tetrahydrofuran
T=50°C; 0.166667 h;
3: With hydrogenchloride
1 h; Heating; Title compound not separated from byproducts;
参考文献
Rose, Nicholas G.W; Blaskovich, Mark A; Wong, Alex; Lajoie, Gilles A
Tetrahedron, 2001 , vol. 57, # 8 p. 1497 - 1507
反应条件
recombinant Bordetella bronchiseptica arylmalonate decarboxylase from E. coli BL21 (DE3)
Enzymatic reaction; optical yield given as percent ee;
参考文献
Okrasa, Krzysztof; Wilding, Matthew; Goodall, Mark; Micklefield, Jason; Levy, Colin; Leys, David; Baudendistel, Nina; Hauer, Bernhard
Angewandte Chemie, International Edition, 2009 , vol. 48, # 41 p. 7691 - 7694
反应条件
hydrazine hydrate in ethanol; acetone
Heating; Yield given;
参考文献
Mulzer, Johann; Angermann, Alfred; Schubert, Boris; Seilz, Carsten
Journal of Organic Chemistry, 1986 , vol. 51, # 26 p. 5294 - 5299
反应条件
hydrogenchloride
1.) water, reflux, 1 h; 2.) EtOH, reflux then propene oxide, reflux, 15 min; Yield given. Multistep reaction;
参考文献
Schoellkopf, Ulrich; Nozulak, Joachim; Groth, Ulrich
Tetrahedron, 1984 , vol. 40, # 8 p. 1409 - 1418
