3-羟基-4-甲氧基苯腈合成路线 （共 23 条）
反应条件
formic acid; hydroxylamine hydrochloride; sodium formate T=85°C; 4 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2012/28939 A1, 2012 ;
Location in patent: Page/Page column 18 ;
反应条件
1: in formic acid T=85°C; 2: With hydroxylammonium sulphate in formic acid T=85°C; 5 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/24703 A1, 2004 ;
Location in patent: Page 14 ;
WO 2004/024703 A1
反应条件
sodium hexamethyldisilazane in tetrahydrofuran T=110°C; 24 h;
参考文献
Hwu, Jih Ru; Hsu, Chia Hao; Wong, Fong Fuh; Chung, Chung-Sun; Hakimelahi, Gholam H.
Synthesis, 1998 , # 3 p. 329 - 332
反应条件
sodium methylate; lauryl mercaptan in N,N-dimethyl-formamide T=100°C; 1 h;
参考文献
Frey, Lisa F.; Marcantonio, Karen M.; Chen, Cheng-Yi; Wallace, Debra J.; Murry, Jerry A.; Tan, Lushi; Chen, Weirong; Dolling, Ulf H.; Grabowski, Edward J. J.
Tetrahedron, 2003 , vol. 59, # 33 p. 6363 - 6373
反应条件
N-bromosuccinmide; K3PO4*7H2O; trimethylsilylazide; copper diacetate in acetonitrile T=80°C; 25 h; Schlenk technique;
参考文献
Zong, Xiaolin; Zheng, Qing-Zhong; Jiao, Ning
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 8 p. 1198 - 1202
反应条件
hydrogen; palladium on activated charcoal
参考文献
Vowinkel,E.; Bartel,J.
Chemische Berichte, 1974 , vol. 107, p. 1221 - 1227
反应条件
1: (i) NH2OH*HCl, Py, (ii) DCC, CuSO4*5H2O, Et3N 2: H2 / Pd-C View Scheme
参考文献
Vowinkel,E.; Bartel,J.
Chemische Berichte, 1974 , vol. 107, p. 1221 - 1227
反应条件
hydrogenchloride; tin man diazotiert das salzsaure Salz des entstandenen Amins mit Natriumnitrit bei -2grad und behandelt die erhaltene Diazoniumsalzloesung mit Kaliumkupfercyanuer;
参考文献
Mameli
Gazzetta Chimica Italiana, 1907 , vol. 37 II, p. 372
反应条件
potassium hydroxide in water; tert-butyl alcohol 8 h; Irradiationthe course of photohydrolysis; Quantum yieldProduct distribution;
参考文献
Kuzmic, Petr; Soucek, Milan
Collection of Czechoslovak Chemical Communications, 1987 , vol. 52, # 4 p. 980 - 988
反应条件
1: 95 percent / K2CO3 / dimethylformamide / 10 h / 85 °C 2: 95 percent / aq. H2SO4; HNO3; AcOH / 50 h / 20 °C 3: 75 percent / sodium dithionite / H2O / 20 - 50 °C 4: 38 percent / KOH / 2-methyl-butan-2-ol / 82 °C View Scheme
参考文献
Wang, Ji-Quan; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 15 p. 4102 - 4106
