3-羟基-4-甲氧基苯腈合成路线 （共 23 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
Kumar, Dalip; Patel, Gautam; Vijayakrishnan, Lalitha; Dastidar, Sunanda G.; Ray, Abhijit
Chemical Biology and Drug Design, 2012 , vol. 79, # 5 p. 810 - 818
反应条件
1.1: Cs2CO3; Triton X-405 / tetrahydrofuran / 5 h / 65 °C
1.2: t-BuOK / tetrahydrofuran / 1 h / -10 - 20 °C
2.1: 79 percent / ZnEt2; Cl3CCO2H / heptane; 1,2-dichloro-ethane / 17 h / -20 - 0 °C
View Scheme
参考文献
Frey, Lisa F.; Marcantonio, Karen M.; Chen, Cheng-Yi; Wallace, Debra J.; Murry, Jerry A.; Tan, Lushi; Chen, Weirong; Dolling, Ulf H.; Grabowski, Edward J. J.
Tetrahedron, 2003 , vol. 59, # 33 p. 6363 - 6373
反应条件
1.1: Cs2CO3; Triton X-405 / tetrahydrofuran / 5 h / 65 °C
1.2: t-BuOK / tetrahydrofuran / 1 h / -10 - 20 °C
2.1: 79 percent / ZnEt2; Cl3CCO2H / heptane; 1,2-dichloro-ethane / 17 h / -20 - 0 °C
3.1: 99 percent / NaOMe; 1-dodecanethiol / dimethylformamide / 1 h / 100 °C
View Scheme
参考文献
Frey, Lisa F.; Marcantonio, Karen M.; Chen, Cheng-Yi; Wallace, Debra J.; Murry, Jerry A.; Tan, Lushi; Chen, Weirong; Dolling, Ulf H.; Grabowski, Edward J. J.
Tetrahedron, 2003 , vol. 59, # 33 p. 6363 - 6373
