1-(2-甲氧基苯基)-3-甲基哌嗪合成路线 (共 15 条)
反应条件
sodium carbonate; palladium on activated charcoal in ethanol
T=20°C; Suzuki-Miyaura cross-coupling; 4 h;
参考文献
Zhang, Guolin
Synthesis, 2005 , # 4 art. no. F15104SS, p. 537 - 542
反应条件
potassium phosphate monobasic monohydrate; palladium diacetate; tri-cyclo-hexyl-phosphine in water; toluene
T=100°C; Suzuki-Miyaura Coupling; 0.166667 h; Microwave irradiationInert atmosphere;
参考文献
Sithebe, Siphamandla; Robinson, Ross S.
Beilstein Journal of Organic Chemistry, 2014 , vol. 10, p. 1107 - 1113
反应条件
Cyphos® IL 101; potassium phosphate; tris(dibenzylideneacetone)dipalladium(0) chloroform complex in toluene
T=50°C; Suzuki cross-coupling; 1 h;
参考文献
McNulty, James; Capretta, Alfredo; Wilson, Jeff; Dyck, Jeff; Adjabeng, George; Robertson, Al
Chemical Communications, 2002 , # 17 p. 1986 - 1987
反应条件
1: methoxybenzene With N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in tetrahydrofuran; cyclohexane
T=-78°C; 2 h;
2: With indium(III) chloride in tetrahydrofuran; cyclohexane
T=-78 - 20°C;
3: para-bromoacetophenone With bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran; cyclohexane
Heating;
参考文献
Pena, Miguel A.; Sestelo, Jose Perez; Sarandeses, Luis A.
Journal of Organic Chemistry, 2007 , vol. 72, # 4 p. 1271 - 1275
反应条件
1: methoxybenzene With N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in tetrahydrofuran; cyclohexane
T=-78°C; 2 h;
2: With indium(III) chloride in tetrahydrofuran; cyclohexane
T=-78 - 20°C;
3: 4-acetylphenyl triflate With bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran; cyclohexane
Heating;
参考文献
Pena, Miguel A.; Sestelo, Jose Perez; Sarandeses, Luis A.
Journal of Organic Chemistry, 2007 , vol. 72, # 4 p. 1271 - 1275
反应条件
(η3-2-methylallyl)Pd(N3)(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene); caesium carbonate in methanol
T=80°C; Suzuki-Miyaura Coupling; 1 h; Schlenk technique;
参考文献
Kim, Hyun-Kyung; Lee, Jung-Hyun; Kim, Yong-Joo; Nu Zheng, Zhen; Lee, Soon W.
European Journal of Inorganic Chemistry, 2013 , # 28 p. 4958 - 4969
反应条件
potassium phosphate; water; tris(dibenzylideneacetone)dipalladium (0) in 1,4-dioxane
T=110°C; Suzuki-Miyaura reaction; 15 h;
参考文献
Billingsley, Kelvin L.; Barder, Timothy E.; Buchwald, Stephen L.
Angewandte Chemie - International Edition, 2007 , vol. 46, # 28 p. 5359 - 5363
反应条件
SPHOS; tris-(dibenzylideneacetone)dipalladium(0); nonafluoro-n-butanesulfonyl fluoride; caesium carbonate in acetonitrile
T=60°C; Suzuki-Miyaura Coupling; 24 h; Inert atmosphere;
参考文献
Ikawa, Takashi; Saito, Kozumo; Akai, Shuji
Synlett, 2012 , vol. 23, # 15 p. 2241 - 2246
反应条件
{C6H3[NHP(piperidinyl)2]2Pd(Cl)}; potassium carbonate in 1,4-dioxane; water; butan-1-ol
T=100°C; Suzuki-Miyaura reaction; 4 h;
参考文献
Bolliger, Jeanne L.; Frech, Christian M.
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 6 p. 1075 - 1080
反应条件
1: 2-methoxybromobenzene With n-butyllithium in tetrahydrofuran; hexane
T=20°C; 0.0166667 h; Inert atmosphere;
2: With tri-isopropoxy-borane in tetrahydrofuran; hexane
T=60°C; 0.0166667 h; Inert atmosphere;
3: para-bromoacetophenone With C45H58ClNPPd; potassium hydroxide in tetrahydrofuran; hexane; water
T=60°C; Suzuki-Miyaura cross-coupling; 0.166667 h; Inert atmosphereSonication;
参考文献
Shu, Wei; Pellegatti, Laurent; Oberli, Matthias A.; Buchwald, Stephen L.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 45 p. 10665 - 10669