sodium hydroxide in water T=100°C; 1.75 h; Yield given. Title compound not separated from byproducts;

sodium hydroxide in water T=100°C; 1.75 h; Yield given. Title compound not separated from byproducts;

1: 80 percent / diethyl ether / 12 h / 25 °C 2: 2.) Ag2O, MgSO4 / 1.) xylene, reflux, 5 d; 2.) RT, 12 h 3: 100 percent / HBr / acetic acid / 5 h / Heating 4: 100 percent / cc H2SO4 / 0.5 h / Ambient temperature 5: NaOH / H2O / 1.75 h / 100 °C View Scheme

1: 100 percent / cc H2SO4 / 0.5 h / Ambient temperature 2: NaOH / H2O / 1.75 h / 100 °C View Scheme

1: 95 percent / NaOH / H2O / 1 h / 70 °C 2: 85 percent / Ac2O / 0.5 h / 70 °C 3: 80 percent / diethyl ether / 12 h / 25 °C 4: 2.) Ag2O, MgSO4 / 1.) xylene, reflux, 5 d; 2.) RT, 12 h 5: 100 percent / HBr / acetic acid / 5 h / Heating 6: 100 percent / cc H2SO4 / 0.5 h / Ambient temperature 7: NaOH / H2O / 1.75 h / 100 °C View Scheme

1: 2.) Ag2O, MgSO4 / 1.) xylene, reflux, 5 d; 2.) RT, 12 h 2: 100 percent / HBr / acetic acid / 5 h / Heating 3: 100 percent / cc H2SO4 / 0.5 h / Ambient temperature 4: NaOH / H2O / 1.75 h / 100 °C View Scheme

1: 85 percent / Ac2O / 0.5 h / 70 °C 2: 80 percent / diethyl ether / 12 h / 25 °C 3: 2.) Ag2O, MgSO4 / 1.) xylene, reflux, 5 d; 2.) RT, 12 h 4: 100 percent / HBr / acetic acid / 5 h / Heating 5: 100 percent / cc H2SO4 / 0.5 h / Ambient temperature 6: NaOH / H2O / 1.75 h / 100 °C View Scheme

1: 100 percent / HBr / acetic acid / 5 h / Heating 2: 100 percent / cc H2SO4 / 0.5 h / Ambient temperature 3: NaOH / H2O / 1.75 h / 100 °C View Scheme

1: 2.) Ag2O, MgSO4 / 1.) xylene, reflux, 5 d; 2.) RT, 12 h 2: 100 percent / HBr / acetic acid / 5 h / Heating 3: 100 percent / cc H2SO4 / 0.5 h / Ambient temperature 4: NaOH / H2O / 1.75 h / 100 °C View Scheme

1: 3.5 percent / Na dichromate, H2SO4 / H2O / 0.5 h / 50 °C 2: 2.) Ag2O, MgSO4 / 1.) xylene, reflux, 5 d; 2.) RT, 12 h 3: 100 percent / HBr / acetic acid / 5 h / Heating 4: 100 percent / cc H2SO4 / 0.5 h / Ambient temperature 5: NaOH / H2O / 1.75 h / 100 °C View Scheme