4-溴-2-乙氧基-1-甲氧基苯合成路线 （共 5 条）
反应条件
sodium hydroxide in water 1.) room temp., 1 h; 2.) reflux, 40 min;
参考文献
Tercio, J.; Ferreira, B.; Catani, V.; Comasseto, J. V.
Synthesis, 1987 , # 2 p. 149 - 153
反应条件
1: 1.) 30percent peracetic acid; 2.) FeSO4 / 1.) acetic acid, room temp., 16 h; 2.) H2O, 20 min 2: 85 percent / NaOH / H2O / 1.) room temp., 1 h; 2.) reflux, 40 min View Scheme
参考文献
Tercio, J.; Ferreira, B.; Catani, V.; Comasseto, J. V.
Synthesis, 1987 , # 2 p. 149 - 153
参考文献
Jona
Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1912 , vol. <5> 21 II, p. 207
反应条件
1: 1-Bromo-3-ethoxy-4-methoxybenzene With tert.-butyl lithium in tetrahydrofuran; pentane T=-78°C; 1 h; 2: tri-isopropoxy-borane in tetrahydrofuran; pentane T=-78 - 20°C; 16 h; 3: With hydrogenchloride; water in tetrahydrofuran; pentane 0.166667 h;
参考文献
Muller, George W.; Chen, Roger Shen-Chu; Man, Hon-Wah; Ruchelman, Alexander L.
Patent: US2007/49618 A1, 2007 ;
Location in patent: Page/Page column 115 ;
反应条件
n-butyllithium in tetrahydrofuran; water
参考文献
Celgene Corporation
Patent: US2005/107339 A1, 2005 ;
