6-溴乙基-喋啶-2,4-二胺合成路线 （共 37 条）
反应条件
bromine; triphenylphosphine in N,N-dimethyl acetamide T=25°C; 18 h;
参考文献
KONINKLIJKE PHILIPS ELECTRONICS N.V.
Patent: WO2007/110811 A2, 2007 ;
Location in patent: Page/Page column 23 ;
反应条件
1: in methanol 2 h; Heating / reflux; 2: With ammonia T=20°C; 2 h; Product distribution / selectivity;
参考文献
Zebala, John A.
Patent: US2006/205729 A1, 2006 ;
Location in patent: Page/Page column 12 ;
反应条件
in methanol 2 h; Heating / reflux;
参考文献
Kamen, Barton; Cole, Peter; Smith, Angela; Zebala, John A.
Patent: US2005/209239 A1, 2005 ;
Location in patent: Page/Page column 17 ;
反应条件
sodium hydroxide; bromine; triphenylphosphine in methanol; glacial AcOH; P2 O5; ethanol
参考文献
The United States of America as represented by the Department of Health, Education and Welfare
Patent: US4077957 A1, 1978 ;
反应条件
ammonium hydroxide; hydrogen bromide; bromine; triphenylphosphine in ethanol; N,N-dimethyl acetamide; water; acetic acid; benzene
参考文献
Research Corporation
Patent: US4820706 A1, 1989 ;
反应条件
BaO in N,N-dimethyl acetamide T=45°C; 21 h; Yield given;
参考文献
Rosowsky; Freisheim; Bader; Forsch; Susten; Cucchi
Journal of Medicinal Chemistry, 1985 , vol. 28, # 5 p. 660 - 667
参考文献
The United States of America as represented by the Department of Health, Education and Welfare
Patent: US4077957 A1, 1978 ;
反应条件
1: BaO / N,N-dimethyl-acetamide / 24 h / 55 °C 2: Ac2O / 2.5 h / Heating 3: 94 percent / Et3N / dimethylformamide / 18 h / 25 °C 4: 74 percent / Et3N / dimethylformamide / 73 h / 55 °C 5: 0.25 N aq. NaOH / 1.75 h / 25 °C View Scheme
参考文献
Rosowsky; Freisheim; Bader; Forsch; Susten; Cucchi
Journal of Medicinal Chemistry, 1985 , vol. 28, # 5 p. 660 - 667
反应条件
1: 720 mg / aq. NaOH / 2-methoxy-ethanol / 24 h / 20 °C View Scheme
参考文献
Vaidya, Chitra M.; Wright, Joel E.; Rosowsky, Andre
Journal of Medicinal Chemistry, 2002 , vol. 45, # 8 p. 1690 - 1696
反应条件
1: 720 mg / aq. NaOH / 2-methoxy-ethanol / 24 h / 20 °C 2: 60 percent / dimethylsulfoxide / 0.5 h / 120 °C View Scheme
参考文献
Vaidya, Chitra M.; Wright, Joel E.; Rosowsky, Andre
Journal of Medicinal Chemistry, 2002 , vol. 45, # 8 p. 1690 - 1696
