6-溴乙基-喋啶-2,4-二胺合成路线 （共 37 条）
反应条件
1: 1.) Ph3P, 2.) NaOMe / 1.) DMF, 60 deg C, 3 h, 2.) DMF, 10 h 2: 34 percent / 2 h / 150 °C 3: 1.) O3, 2.) Me2S / 1.) CH2Cl2, MeOH, -78 deg C, 30 min, 2.) CH2Cl2, MeOH, 0 deg C, 2 h 4: 63 percent / NaBH4 / CH2Cl2; propan-2-ol / 0.5 h / -10 °C 5: 77 percent / 1N aq. NaOH / dimethylformamide / 4 h / Ambient temperature View Scheme
参考文献
Matsuoka, Hiroharu; Kuroki, Toshio; Yano, Keiichi; Takeda, Yasuhisa
Journal of Labelled Compounds and Radiopharmaceuticals, 1997 , vol. 39, # 5 p. 363 - 368
反应条件
BaO in N,N-dimethyl acetamide T=55°C; 24 h;
参考文献
Rosowsky; Freisheim; Bader; Forsch; Susten; Cucchi
Journal of Medicinal Chemistry, 1985 , vol. 28, # 5 p. 660 - 667
参考文献
Vaidya, Chitra M.; Wright, Joel E.; Rosowsky, Andre
Journal of Medicinal Chemistry, 2002 , vol. 45, # 8 p. 1690 - 1696
反应条件
N,N-dimethyl acetamide; N-ethyl-N,N-diisopropylamine T=20°C; 72 h;
参考文献
KONINKLIJKE PHILIPS ELECTRONICS N.V.
Patent: WO2007/110811 A2, 2007 ;
Location in patent: Page/Page column 23 ;
反应条件
hydrogenchloride in sodium hydroxide
参考文献
The United States of America as represented by the Department of Health, Education and Welfare
Patent: US4077957 A1, 1978 ;
反应条件
triethylamine in N,N-dimethyl acetamide
T=25°C; 120 h; Yield given;
参考文献
Piper; Montgomery; Sirotnak; Chello
Journal of Medicinal Chemistry, 1982 , vol. 25, # 2 p. 182 - 187
反应条件
in N,N-dimethyl acetamide
T=25°C; 120 h; Yield given;
参考文献
Piper; Montgomery; Sirotnak; Chello
Journal of Medicinal Chemistry, 1982 , vol. 25, # 2 p. 182 - 187
反应条件
in N,N-dimethyl acetamide
T=25°C; 120 h; Yield given;
参考文献
Piper; Montgomery; Sirotnak; Chello
Journal of Medicinal Chemistry, 1982 , vol. 25, # 2 p. 182 - 187
反应条件
in N,N-dimethyl acetamide
T=25°C; 120 h; Yield given;
参考文献
Piper; Montgomery; Sirotnak; Chello
Journal of Medicinal Chemistry, 1982 , vol. 25, # 2 p. 182 - 187
反应条件
in N,N-dimethyl acetamide
T=25°C; 120 h; Yield given;
参考文献
Piper; Montgomery; Sirotnak; Chello
Journal of Medicinal Chemistry, 1982 , vol. 25, # 2 p. 182 - 187
