6-溴乙基-喋啶-2,4-二胺合成路线 （共 37 条）
反应条件
in N,N-dimethyl acetamide
T=25°C; 120 h; Yield given;
参考文献
Piper; Montgomery; Sirotnak; Chello
Journal of Medicinal Chemistry, 1982 , vol. 25, # 2 p. 182 - 187
反应条件
in N,N-dimethyl acetamide
T=25°C; 120 h; Yield given;
参考文献
Piper; Montgomery; Sirotnak; Chello
Journal of Medicinal Chemistry, 1982 , vol. 25, # 2 p. 182 - 187
反应条件
in N,N-dimethyl acetamide
T=25°C; 120 h; Yield given;
参考文献
Piper; Montgomery; Sirotnak; Chello
Journal of Medicinal Chemistry, 1982 , vol. 25, # 2 p. 182 - 187
反应条件
in N,N-dimethyl acetamide
T=25°C; 120 h; Yield given;
参考文献
Piper; Montgomery; Sirotnak; Chello
Journal of Medicinal Chemistry, 1982 , vol. 25, # 2 p. 182 - 187
反应条件
1: Me2NAc / 1.5 h / 60 - 63 °C
2: NaOMe / various solvent(s) / 17 h / 25 °C
View Scheme
参考文献
Piper, James R.; Montgomery, John A.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 3 p. 320 - 321
反应条件
in N,N-dimethyl acetamide
T=25°C; 144 h;
参考文献
Piper, James R.; McCaleb, George S.; Montgomery, John A.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 291 - 294
反应条件
in N,N-dimethyl acetamide
T=25°C; 120 h; Yield given;
参考文献
Piper; Montgomery; Sirotnak; Chello
Journal of Medicinal Chemistry, 1982 , vol. 25, # 2 p. 182 - 187
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl acetamide
T=45 - 50°C; 25 h; Yield given;
参考文献
Rosowsky; Freisheim; Bader; Forsch; Susten; Cucchi
Journal of Medicinal Chemistry, 1985 , vol. 28, # 5 p. 660 - 667
反应条件
1: i-Pr2NEt / N,N-dimethyl-acetamide / 48 h / 45 °C
2: 86 percent / aq. Ba(OH)2 / 22 h
View Scheme
参考文献
Rosowsky; Freisheim; Bader; Forsch; Susten; Cucchi
Journal of Medicinal Chemistry, 1985 , vol. 28, # 5 p. 660 - 667
反应条件
1: BaO / N,N-dimethyl-acetamide / 24 h / 55 °C
2: Ac2O / 2.5 h / Heating
View Scheme
参考文献
Rosowsky; Freisheim; Bader; Forsch; Susten; Cucchi
Journal of Medicinal Chemistry, 1985 , vol. 28, # 5 p. 660 - 667
