反应条件
1: 1.) Ph3P, 2.) NaOMe / 1.) DMF, 60 deg C, 3 h, 2.) DMF, 10 h
2: 34 percent / 2 h / 150 °C
3: 1.) O3, 2.) Me2S / 1.) CH2Cl2, MeOH, -78 deg C, 30 min, 2.) CH2Cl2, MeOH, 0 deg C, 2 h
4: 63 percent / NaBH4 / CH2Cl2; propan-2-ol / 0.5 h / -10 °C
5: 77 percent / 1N aq. NaOH / dimethylformamide / 4 h / Ambient temperature
6: 1.) 47percent aq. HBr, 2.) Ph3PBr2 / 1.) EtOH, reflux, 15 min, 2.) DMF, RT, 4 h
View Scheme
参考文献
Matsuoka, Hiroharu; Kuroki, Toshio; Yano, Keiichi; Takeda, Yasuhisa
Journal of Labelled Compounds and Radiopharmaceuticals, 1997 , vol. 39, # 5 p. 363 - 368
