4-氯-6-甲氧基-5-硝基嘧啶合成路线 （共 5 条）
反应条件
1: 74 percent / 57percent aq. HI / 24 h / Ambient temperature 2: 85 percent / 20percent TiCl3, AcOH / H2O / 18 h / Ambient temperature 3: 75 percent / 2 h / 100 °C 4: 37 percent / Et4NCl, Pd(PPh3)2Cl2 / acetonitrile / 33 h / Heating 5: 94 percent / concd. HCl / methanol / 5 h / Heating View Scheme
参考文献
Brakta, Mohamed; Daves, G. Doyle
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 15 p. 1883 - 1884
反应条件
hydrogen; palladium 10 on activated carbon in ethanol T=20°C; P=1500.15 Torr;
参考文献
ALMIRALL, S.A.; EASTWOOD, Paul Robert; GONZALEZ RODRIGUEZ, Jacob; GOMEZ CASTILLO, Elena; BACH TANA, Jordi
Patent: WO2012/160030 A1, 2012 ;
Location in patent: Page/Page column 139 ;
反应条件
in methanol
T=0°C; 2 h;
参考文献
MERCK SHARP and DOHME LIMITED
Patent: WO2004/41826 A1, 2004 ;
Location in patent: Page 42 ;
反应条件
sodium hydride in N,N-dimethyl-formamide
1.5 h;
参考文献
Remennikov, G. Ya.; Kisilenko, A. A.; Cherkasov, V. M.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , p. 1109 - 1112
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , vol. 19, # 10 p. 1393 - 1397
参考文献
Nemeryuk, M. P.; Sedov, A. L.; Makarov, V. A.; Solov'eva, N. P.; Safonova, T. S.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1991 , vol. 27, # 7 p. 804 - 805
Khimiya Geterotsiklicheskikh Soedinenii, 1991 , # 7 p. 999 - 1000
