乙基2-乙基-2-(3-羟基丙基)环丙烷羧酸酯合成路线 （共 6 条）
反应条件
hydrogen; 5percent Pd/C in ethanol; dichloromethane; ethyl acetate
T=18°C; P=760.051 Torr; 22 h;
参考文献
Banwell, Martin G.; Edwards, Alison J.; Jolliffe, Katrina A.; Smith, Jason A.; Hamel, Ernest; Verdier-Pinard, Pascal
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 2 p. 296 - 305
反应条件
1.1: NaHMDS / tetrahydrofuran / 1.5 h / 18 °C
1.2: 30 percent / tetrahydrofuran / 15 h / 18 °C
2.1: 57 percent / LiAlH4 / diethyl ether / 1.5 h
3.1: 70 percent / NaH; NaI / dimethylformamide / 18 h / 18 °C
4.1: Rh2(OAc)4 / CH2Cl2 / 0.5 h / 18 °C
5.1: 210 mg / H2 / 5percent Pd/C / CH2Cl2; ethyl acetate; ethanol / 22 h / 18 °C / 760.05 Torr
View Scheme
参考文献
Banwell, Martin G.; Edwards, Alison J.; Jolliffe, Katrina A.; Smith, Jason A.; Hamel, Ernest; Verdier-Pinard, Pascal
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 2 p. 296 - 305
反应条件
1.1: 95 percent / aq. NaHCO3; K2CO3; Oxone / acetone / 29 h / 18 °C
2.1: NaHMDS / tetrahydrofuran / 1.5 h / 18 °C
2.2: 30 percent / tetrahydrofuran / 15 h / 18 °C
3.1: 57 percent / LiAlH4 / diethyl ether / 1.5 h
4.1: 70 percent / NaH; NaI / dimethylformamide / 18 h / 18 °C
5.1: Rh2(OAc)4 / CH2Cl2 / 0.5 h / 18 °C
6.1: 210 mg / H2 / 5percent Pd/C / CH2Cl2; ethyl acetate; ethanol / 22 h / 18 °C / 760.05 Torr
View Scheme
参考文献
Banwell, Martin G.; Edwards, Alison J.; Jolliffe, Katrina A.; Smith, Jason A.; Hamel, Ernest; Verdier-Pinard, Pascal
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 2 p. 296 - 305
反应条件
1: 70 percent / NaH; NaI / dimethylformamide / 18 h / 18 °C
2: Rh2(OAc)4 / CH2Cl2 / 0.5 h / 18 °C
3: 210 mg / H2 / 5percent Pd/C / CH2Cl2; ethyl acetate; ethanol / 22 h / 18 °C / 760.05 Torr
View Scheme
参考文献
Banwell, Martin G.; Edwards, Alison J.; Jolliffe, Katrina A.; Smith, Jason A.; Hamel, Ernest; Verdier-Pinard, Pascal
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 2 p. 296 - 305
反应条件
1: 57 percent / LiAlH4 / diethyl ether / 1.5 h
2: 70 percent / NaH; NaI / dimethylformamide / 18 h / 18 °C
3: Rh2(OAc)4 / CH2Cl2 / 0.5 h / 18 °C
4: 210 mg / H2 / 5percent Pd/C / CH2Cl2; ethyl acetate; ethanol / 22 h / 18 °C / 760.05 Torr
View Scheme
参考文献
Banwell, Martin G.; Edwards, Alison J.; Jolliffe, Katrina A.; Smith, Jason A.; Hamel, Ernest; Verdier-Pinard, Pascal
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 2 p. 296 - 305
反应条件
1: Rh2(OAc)4 / CH2Cl2 / 0.5 h / 18 °C
2: 210 mg / H2 / 5percent Pd/C / CH2Cl2; ethyl acetate; ethanol / 22 h / 18 °C / 760.05 Torr
View Scheme
参考文献
Banwell, Martin G.; Edwards, Alison J.; Jolliffe, Katrina A.; Smith, Jason A.; Hamel, Ernest; Verdier-Pinard, Pascal
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 2 p. 296 - 305
