N-(2,6-二甲基苯基)丙氨酸甲酯合成路线 （共 11 条）
反应条件
sodium hydrogencarbonate in N-methyl-acetamide; toluene
参考文献
Montedison S.p.A.
Patent: US4291049 A1, 1981 ;
反应条件
1: HCl / H2O 2: 100 percent / SOCl2 3: Burkholderia cepacia lipase PS; Triton X-100; phosphate buffer / H2O / 3 h / 30 °C / pH 7.0 4: 93 percent / SOCl2 / 3 h / Heating 5: 99 percent / NaHCO3 / toluene / 1 h / 0 - 20 °C View Scheme
参考文献
Park, Oh-Jin; Lee, Sang-Hyun; Park, Tae-Yoon; Lee, Sang-Who; Cho, Koon-Ho
Tetrahedron Asymmetry, 2005 , vol. 16, # 6 p. 1221 - 1225
反应条件
(i), (ii) (racemate resolution); Multistep reaction;
参考文献
Ciba-Geigy
Patent: CH607888 , 1978 ;
Chem.Abstr., 1979 , vol. 90, # 147008
参考文献
Ciba-Geigy Corporation
Patent: US4317916 A1, 1982 ;
反应条件
hydrogen; sodium sulfate; palladium on activated charcoal in cyclohexane
P=37503 Torr; Ambient temperature;
参考文献
Fache, Fabienne; Valot, Frederic; Milenkovic, Alexandra; Lemaire, Marc
Tetrahedron, 1996 , vol. 52, # 29 p. 9777 - 9784
反应条件
hydrogen; sodium sulfate; palladium on activated charcoal in cyclohexane
P=37503 Torr; Ambient temperature;
参考文献
Fache, Fabienne; Valot, Frederic; Milenkovic, Alexandra; Lemaire, Marc
Tetrahedron, 1996 , vol. 52, # 29 p. 9777 - 9784
反应条件
sodium iodide; sodium carbonate in water
参考文献
Ciba-Geigy Corporation
Patent: US4267356 A1, 1981 ;
反应条件
sodium iodide; tetra-(n-butyl)ammonium iodide; sodium carbonate in water
参考文献
Ciba-Geigy Corporation
Patent: US4260782 A1, 1981 ;
反应条件
butyraldehyde; benzoic acid in toluene
2 h; Heating;
参考文献
Park, Oh-Jin; Lee, Sang-Hyun; Park, Tae-Yoon; Lee, Sang-Who; Cho, Koon-Ho
Tetrahedron Asymmetry, 2005 , vol. 16, # 6 p. 1221 - 1225
反应条件
phosphate buffer; Burkholderia cepacia lipase PS; Triton X-100 in water
T=30°C; pH=7.0; 24 h;
参考文献
Park, Oh-Jin; Lee, Sang-Hyun; Park, Tae-Yoon; Lee, Sang-Who; Cho, Koon-Ho
Tetrahedron Asymmetry, 2005 , vol. 16, # 6 p. 1221 - 1225
