3-(N-叔丁氧基羰基-n-甲基氨基)苯胺合成路线 （共 5 条）
反应条件
hydrogen; palladium on activated charcoal in tetrahydrofuran; methanol
参考文献
JAMES BLACK FOUNDATION LIMITED
Patent: WO2004/98609 A1, 2004 ;
Location in patent: Page/Page column 24-25 ;
反应条件
1.1: NaH / dimethylformamide / 1 h / 20 °C
1.2: 88 percent / dimethylformamide / 2 h / 20 °C
2.1: 99 percent / H2 / Pd/C / methanol; tetrahydrofuran
View Scheme
参考文献
McDonald, Iain M.; Austin, Carol; Buck, Ildiko M.; Dunstone, David J.; Griffin, Eric; Harper, Elaine A.; Hull, Robert A. D.; Kalindjian, S. Barret; Linney, Ian D.; Low, Caroline M. R.; Pether, Michael J.; Spencer, John; Wright, Paul T.; Adatia, Trushar; Bashall, Alan
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2253 - 2261
反应条件
1.1: 95 percent / 2 h / Heating
2.1: NaH / dimethylformamide / 1 h / 20 °C
2.2: 88 percent / dimethylformamide / 2 h / 20 °C
3.1: 99 percent / H2 / Pd/C / methanol; tetrahydrofuran
View Scheme
参考文献
McDonald, Iain M.; Austin, Carol; Buck, Ildiko M.; Dunstone, David J.; Griffin, Eric; Harper, Elaine A.; Hull, Robert A. D.; Kalindjian, S. Barret; Linney, Ian D.; Low, Caroline M. R.; Pether, Michael J.; Spencer, John; Wright, Paul T.; Adatia, Trushar; Bashall, Alan
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2253 - 2261
反应条件
1: tert-butyl alcohol / 20 h / 60 °C
2: caesium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C
3: hydrogen / palladium 10 on activated carbon / methanol / 19 h / 20 °C
View Scheme
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: US2011/237620 A1, 2011 ;
US 20110237620 A1
反应条件
1: tert-butyl alcohol / 20 h / 60 °C
2: caesium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C
3: hydrogen / palladium 10 on activated carbon / methanol / 19 h / 20 °C
View Scheme
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: US2011/237620 A1, 2011 ;
US 20110237620 A1
