反应条件
1: morpholine / isopropyl alcohol / 1 h / 20 - 33 °C
2: triethylamine / methanol / 66.02 h / 25 °C / |Reflux
3: trichlorophosphate / 10 h / 135 °C
4: methanol / 18.75 h / 18 - 25 °C
5: sulfuric acid / toluene / 120 h / 70 °C
6: hydrogen; triethylamine; 20 palladium(II) hydroxide on carbon / methanol / 21 h / 25 °C / 1613.54 - 2078.99 Torr
7: N-bromosuccinmide / dichloromethane / -5 °C
8: lithium aluminium tetrahydride / tetrahydrofuran
9: N-ethyl-N,N-diisopropylamine / dichloromethane / 40 °C
View Scheme
参考文献
Harrington, Peter J.; Johnston, Dave; Moorlag, Henk; Wong, Jim-Wah; Hodges, L. Mark; Harris, Les; McEwen, Gerald K.; Smallwood, Blair
Organic Process Research and Development, 2006 , vol. 10, # 6 p. 1157 - 1166