反应条件
1: methanol; water / 0.33 h / 20 °C
2: sodium tetrahydroborate / methanol; water / 2.5 h / 0 - 20 °C
3: triethylamine / dichloromethane / 18 h / 20 °C
4: sodium tetrahydroborate / ethanol / 1.5 h / 0 - 20 °C
5: sulfuric acid / dichloromethane / 0.33 h / 0 - 20 °C
6: Chiracel™ AD column / hexane; isopropyl alcohol / |Resolution of racemate
View Scheme
参考文献
Pechulis, Anthony D.; Beck, James P.; Curry, Matt A.; Wolf, Mark A.; Harms, Arthur E.; Xi, Ning; Opalka, Chet; Sweet, Mark P.; Yang, Zhicai; Vellekoop, A. Samuel; Klos, Andrew M.; Crocker, Peter J.; Hassler, Carla; Laws, Mia; Kitchen, Douglas B.; Smith, Mark A.; Olson, Richard E.; Liu, Shuang; Molino, Bruce F.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 23 p. 7219 - 7222
