1,2,3,4-四氢-1-萘酚合成路线 （共 211 条）
反应条件
1: 1-hydroxy-1,2,3,4-tetrahydronaphthalene With (-)-Tetramisole; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=-78°C; Inert atmosphereMolecular sieveResolution of racemate; 2: tris(4-bromophenyl)chlorosilane in tetrahydrofuran T=-78°C; 24 h; Inert atmosphereMolecular sieveResolution of racemate; enantioselective reaction;
参考文献
Akhani, Ravish K.; Moore, Maggie I.; Pribyl, Julia G.; Wiskur, Sheryl L.
Journal of Organic Chemistry, 2014 , vol. 79, # 6 p. 2384 - 2396
反应条件
1: 1-hydroxy-1,2,3,4-tetrahydronaphthalene With (-)-Tetramisole; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=-78°C; Inert atmosphereMolecular sieveResolution of racemate; 2: chlorotris(4-chlorophenyl)silane in tetrahydrofuran T=-78°C; 24 h; Inert atmosphereMolecular sieveResolution of racemate; enantioselective reaction;
参考文献
Akhani, Ravish K.; Moore, Maggie I.; Pribyl, Julia G.; Wiskur, Sheryl L.
Journal of Organic Chemistry, 2014 , vol. 79, # 6 p. 2384 - 2396
反应条件
triethylamine in hexane T=20°C; Acylation; 144 h; Title compound not separated from byproducts;
参考文献
Yamada, Shinji; Katsumata, Hiroko
Journal of Organic Chemistry, 1999 , vol. 64, # 26 p. 9365 - 9373
反应条件
triethylamine in hexane T=20°C; Acylation; 14 h; Title compound not separated from byproducts;
参考文献
Yamada, Shinji; Katsumata, Hiroko
Journal of Organic Chemistry, 1999 , vol. 64, # 26 p. 9365 - 9373
反应条件
1: 1-hydroxy-1,2,3,4-tetrahydronaphthalene With (-)-Tetramisole; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=-78°C; Inert atmosphereMolecular sieveResolution of racemate; 2: chlorotris(4-methoxyphenyl)silane in tetrahydrofuran T=-78°C; 48 h; Inert atmosphereMolecular sieveResolution of racemate; enantioselective reaction;
参考文献
Akhani, Ravish K.; Moore, Maggie I.; Pribyl, Julia G.; Wiskur, Sheryl L.
Journal of Organic Chemistry, 2014 , vol. 79, # 6 p. 2384 - 2396
反应条件
1: 1-hydroxy-1,2,3,4-tetrahydronaphthalene With (-)-Tetramisole; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=-78°C; Inert atmosphereMolecular sieveResolution of racemate; 2: tris([1,1′-biphenyl]-4-yl)chlorosilane in tetrahydrofuran T=-78°C; 72 h; Inert atmosphereMolecular sieveResolution of racemate; enantioselective reaction;
参考文献
Akhani, Ravish K.; Moore, Maggie I.; Pribyl, Julia G.; Wiskur, Sheryl L.
Journal of Organic Chemistry, 2014 , vol. 79, # 6 p. 2384 - 2396
反应条件
2-acetyloxy-1-propene; lipase YS in di-isopropyl ether T=30°C; 7 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Naemura, Koichiro; Fukuda, Ritsuko; Konishi, Masayoshi; Hirose, Keiji; Tobe, Yoshito
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 10 p. 1253 - 1256
反应条件
lipase YS in di-isopropyl ether T=30°C; 7 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Naemura, Koichiro; Fukuda, Ritsuko; Konishi, Masayoshi; Hirose, Keiji; Tobe, Yoshito
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 10 p. 1253 - 1256
反应条件
(-)-Tetramisole; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=-78°C; 20 h; Inert atmosphereMolecular sieve; optical yield given as percent ee;
参考文献
Klauck, Maggie I.; Patel, Sachin G.; Wiskur, Sheryl L.
Journal of Organic Chemistry, 2012 , vol. 77, # 7 p. 3570 - 3575
反应条件
1: 4-(N,N-dimethlyamino)pyridine; triethylamine / diethyl ether 2: sodium carbonate / toluene / 72 h / 40 °C / Enzymatic reaction View Scheme
参考文献
Houiene, Zahia; Merabet-Khelassi, Mounia; Bouzemi, Nassima; Riant, Olivier; Aribi-Zouioueche, Louisa
Tetrahedron Asymmetry, 2013 , vol. 24, # 5-6 p. 290 - 296
