1,2,3,4-四氢-1-萘酚合成路线 （共 211 条）
反应条件
1: 91 percent / SOCl2 / CHCl3 / 1 h / 60 °C 2: 79 percent / 18-crown-6 / acetonitrile / 5 h / Heating 3: 30percent aq. NaOH / methanol / 12 h / Heating View Scheme
参考文献
Reimann; Speckbacher
Archiv der Pharmazie, 1989 , vol. 322, # 12 p. 889 - 892
反应条件
1: 2-methyl-butan-2-ol / Heating 2: Pd-C / 180 °C View Scheme
参考文献
Felix,D. et al.
Helvetica Chimica Acta, 1969 , vol. 52, p. 1030 - 1042
反应条件
1: 93 percent / oxalic acid / H2O / 6 h / Heating
2: 1.) formic acid, 30 percent hydrogen peroxide; 2.) 20 percent H2SO4 / 1.) 35 deg C, 2 h, room temp., 12 h; 2.) reflux, 10 h
3: 93 percent / NaH / benzene / 5 h / 65 - 70 °C
4: NaBH4 / methanol / 4 h / Ambient temperature
5: p-toluenesulfonic acid / 1.) room temp., 1h; 2.) 65 deg C, 6 h
View Scheme
参考文献
Vebrel, Joel; Carrie, Robert
Bulletin de la Societe Chimique de France, 1982 , vol. 2, # 5-6 p. 161 - 166
反应条件
trichlorophosphate
T=0 - 20°C;
参考文献
COUNCIL OF SCIENTIFIC and INDUSTRIAL RESEARCH
Patent: WO2009/110002 A1, 2009 ;
Location in patent: Page/Page column 44; 45 ;
反应条件
bromine; 1,2-bis-(diphenylphosphino)ethane in dichloromethane
T=-15 - 20°C; Bromination;
参考文献
Braslau, Rebecca; Naik, Neeta; Zipse, Hendrik
Journal of the American Chemical Society, 2000 , vol. 122, # 35 p. 8421 - 8434
反应条件
[Ir2(COD)2(SnCl3)2(Cl)2)(μ-Cl)2] in 1,2-dichloro-ethane
T=80°C; 5 h; Title compound not separated from byproducts.;
参考文献
Podder, Susmita; Choudhury, Joyanta; Roy, Sujit
Journal of Organic Chemistry, 2007 , vol. 72, # 8 p. 3129 - 3132
反应条件
sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate
3.5 h; below 25 deg C;
参考文献
Mouzin, Gilbert; Cousse, Henri; Rieu, Jean-Pierre; Duflos, Alain
Synthesis, 1983 , # 2 p. 117 - 119
反应条件
diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene in toluene
Inert atmosphere;
参考文献
Kuliszewska, Edyta; Hanbauer, Martin; Hammerschmidt, Friedrich
Chemistry - A European Journal, 2008 , vol. 14, # 28 p. 8603 - 8614
反应条件
1: With n-butyllithium in hexane
T=40°C; 1 h; Inert atmosphere;
2: With 1,2-dibromo-1,1,2,2-tetrachloroethane in hexane
T=25°C; 4 h; Inert atmosphere;
参考文献
Brucks, Alexandria P.; Treitler, Daniel S.; Liu, Shu-An; Snyder, Scott A.
Synthesis (Germany), 2013 , vol. 45, # 13 art. no. SS-2013-C0294-OP, p. 1886 - 1898
反应条件
1: 2-methyl-butan-2-ol / Heating
2: Pd-C / 180 °C
3: (i) <Et3O>BF4, CH2Cl2, (ii) aq. KOH, MeOH
4: SOCl2
View Scheme
参考文献
Felix,D. et al.
Helvetica Chimica Acta, 1969 , vol. 52, p. 1030 - 1042
