1: 3-(4-chloro-phenyl)-2-cyano-propionic acid ethyl ester With potassium hydride in acetonitrile T=20°C; 0.333333 h; Inert atmosphereGlovebox; 2: 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium in acetonitrile T=24.84°C; Inert atmosphereGlovebox; Thermodynamic data;

ethanol; sodium in ethanol 7 h; Heating;

1.1: sodium hydride / tetrahydrofuran / 0.25 h / |Inert atmosphere 1.2: 16 h / 35 °C / |Inert atmosphere 2.1: N,N,N',N'-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a;2',1'-c][1,4] diazepine-2,12-diamine / N,N-dimethyl-formamide / 36 h / 20 °C / |Inert atmosphere; |Glovebox; |UV-irradiation 2.2: 0 °C / pH < 3 / |Inert atmosphere View Scheme