1.1: potassium tert-butylate / tetrahydrofuran / 0 - 30 °C / |Inert atmosphere
1.2: 1.75 h / 0 - 5 °C / |Inert atmosphere
2.1: potassium hydroxide / tetrahydrofuran; ethanol; water / 18 h / -10 - 0 °C / |Inert atmosphere
3.1: potassium tert-butylate / tetrahydrofuran; tert-butyl alcohol / 5 h / -5 - 0 °C / |Inert atmosphere
4.1: ethyl acetate / 18 h / 20 - 40 °C / |Cooling
5.1: [RuCl(p-cumene)((S)-2,2-bis(diphenylphosphino)-1,1-binaphthyl)]chloride; hydrogen / methanol / 40 h / 60 °C / 3102.97 Torr
5.2: 16 h / 20 - 40 °C
6.1: citric acid / dichloromethane; water
View Scheme
参考文献
Ashcroft, Christopher P.; Challenger, Stephen; Derrick, Andrew M.; Storey, Richard; Thomson, Nicholas M.
Organic Process Research and Development, 2003 , vol. 7, # 3 p. 362 - 368
1.1: potassium tert-butylate / tetrahydrofuran / 0 - 30 °C / |Inert atmosphere
1.2: 1.75 h / 0 - 5 °C / |Inert atmosphere
2.1: potassium hydroxide / tetrahydrofuran; ethanol; water / 18 h / -10 - 0 °C / |Inert atmosphere
3.1: potassium tert-butylate / tetrahydrofuran; tert-butyl alcohol / 5 h / -5 - 0 °C / |Inert atmosphere
4.1: ethyl acetate / 18 h / 20 - 40 °C / |Cooling
5.1: [RuCl(p-cumene)((S)-2,2-bis(diphenylphosphino)-1,1-binaphthyl)]chloride; hydrogen / methanol / 40 h / 60 °C / 3102.97 Torr
5.2: 16 h / 20 - 40 °C
6.1: citric acid / dichloromethane; water
7.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 - 20 °C
View Scheme
参考文献
Ashcroft, Christopher P.; Challenger, Stephen; Derrick, Andrew M.; Storey, Richard; Thomson, Nicholas M.
Organic Process Research and Development, 2003 , vol. 7, # 3 p. 362 - 368
