反应条件
1.1: acetone / 1 h
2.1: potassium carbonate / dichloromethane; water / 1.5 h / 0 °C
2.2: 3 h / 5 °C
3.1: dichloromethane; 2,2,2-trifluoroethanol / 4.17 h / 10 °C
View Scheme
参考文献
Monn, James A.; Valli, Matthew J.; Massey, Steven M.; Hao, Junliang; Reinhard, Matthew R.; Bures, Mark G.; Heinz, Beverly A.; Wang, Xushan; Carter, Joan H.; Getman, Brian G.; Stephenson, Gregory A.; Herin, Marc; Catlow, John T.; Swanson, Steven; Johnson, Bryan G.; McKinzie, David L.; Henry, Steven S.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 11 p. 4442 - 4455
