反应条件
1.1: iodine; triphenylphosphine; imidazole / diethyl ether; acetonitrile / 1 h / 0 °C
2.1: n-butyllithium / tetrahydrofuran
2.2: tetrahydrofuran; hexamethylphosphoric acid triamide / 1 h / 20 °C
3.1: lithium; ethylamine / 1 h / -5 °C
4.1: p-toluenesulfonic acid / ethanol / 3 h / Heating
5.1: 93 percent / pyridine / 0.5 h / 20 °C
View Scheme
参考文献
Naka, Hideshi; Nakazawa, Tomotake; Sugie, Mieko; Yamamoto, Masanobu; Horie, Yoshiteru; Wakasugi, Ryohei; Arita, Yutaka; Sugie, Hajime; Tsuchida, Koji; Ando, Tetsu
Bioscience, Biotechnology and Biochemistry, 2006 , vol. 70, # 2 p. 508 - 516