甲基2-乙基-2-甲基丁酸酯合成路线 （共 16 条）
反应条件
1: With sodium hydroxide in methanol T=60°C; 2: With hydrogenchloride in methanol; water
参考文献
Wu, Xuesong; Zhao, Yan; Zhang, Guangwu; Ge, Haibo
Angewandte Chemie - International Edition, 2014 , vol. 53, # 14 p. 3706 - 3710
Angew.Chem.Int.Ed., 2014 , vol. 126, # 14 p. 3780 - 3794,5
反应条件
lithium diisopropyl amide in tetrahydrofuran; n-heptane
1.) -78 deg C, 0.5 h, 2.) RT;
参考文献
Rouchaud, J.; Gustin, F.; Moulard, C.
Bulletin des Societes Chimiques Belges, 1993 , vol. 102, # 8 p. 545 - 556
反应条件
1: bromine
2: diethyl ether
View Scheme
参考文献
Sarel; Newman
Journal of the American Chemical Society, 1956 , vol. 78, p. 5416,5418
参考文献
Sarel; Newman
Journal of the American Chemical Society, 1956 , vol. 78, p. 5416,5418
反应条件
1: SOCl2 / 2 h / Heating
2: 2 h / Heating
3: 1.) LDA / 1.) THF, n-heptane, -78 deg C, 0.5 h, 2.) THF, n-heptane, a) -78 deg C, 0.5 h, b) from -78 deg C to RT, 2 h, c) RT, overnight
View Scheme
参考文献
Rouchaud; Gustin; Callens; Vanhimme; Bulcke
1993 , vol. 41, # 11 p. 2142 - 2148
反应条件
1: 2 h / Heating
2: 1.) LDA / 1.) THF, n-heptane, -78 deg C, 0.5 h, 2.) THF, n-heptane, a) -78 deg C, 0.5 h, b) from -78 deg C to RT, 2 h, c) RT, overnight
View Scheme
参考文献
Rouchaud; Gustin; Callens; Vanhimme; Bulcke
1993 , vol. 41, # 11 p. 2142 - 2148
反应条件
(+/-)-2-methylbutanoic acid methyl ester; di-tert-butyl peroxide
T=140°C; P=30400 - 38000 Torr; 3 h; Further byproducts given. Title compound not separated from byproducts;
参考文献
Terent'ev, A. B.; Dostovalova, V. I.; Ikonnikov, N. S.; Moskalenko, M. A.; Freidlina, R. Kh.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1980 , vol. 29, # 3 p. 377 - 382
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1980 , # 3 p. 558 - 563
反应条件
isovaleric acid methyl ester; di-tert-butyl peroxide
T=140°C; P=30400 - 38000 Torr; 3 h; Further byproducts given. Title compound not separated from byproducts;
参考文献
Terent'ev, A. B.; Dostovalova, V. I.; Ikonnikov, N. S.; Moskalenko, M. A.; Freidlina, R. Kh.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1980 , vol. 29, # 3 p. 377 - 382
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1980 , # 3 p. 558 - 563
反应条件
isovaleric acid methyl ester; di-tert-butyl peroxide
T=140°C; P=30400 - 38000 Torr; 3 h; Further byproducts given. Title compound not separated from byproducts;
参考文献
Terent'ev, A. B.; Dostovalova, V. I.; Ikonnikov, N. S.; Moskalenko, M. A.; Freidlina, R. Kh.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1980 , vol. 29, # 3 p. 377 - 382
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1980 , # 3 p. 558 - 563
反应条件
isovaleric acid methyl ester; di-tert-butyl peroxide
T=140°C; P=30400 - 38000 Torr; 3 h; Further byproducts given. Title compound not separated from byproducts;
参考文献
Terent'ev, A. B.; Dostovalova, V. I.; Ikonnikov, N. S.; Moskalenko, M. A.; Freidlina, R. Kh.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1980 , vol. 29, # 3 p. 377 - 382
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1980 , # 3 p. 558 - 563
