2-羧甲基-5-甲氧基苯甲酸合成路线 （共 14 条）
反应条件
sulfuric acid
T=60°C; 2 h;
参考文献
Hill, Ronald A.; Rudra, Sonali; Peng, Bo; Roane, David S.; Bounds, Jeffrey K.; Zhang, Yang; Adloo, Ahmad; Lu, Tiansheng
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 9 p. 2099 - 2113
反应条件
in toluene
T=105°C; 12 h;
参考文献
AbbVie Inc.; Abbott GmbH and Co. KG; Geneste, Hervé; Ochse, Michael; Drescher, Karla; Dinges, Jürgen; Jakob, Clarissa
Patent: US2013/116229 A1, 2013 ;
Location in patent: Paragraph 0989; 0990 ;
反应条件
1: 84 percent / zinc; acetic acid
2: 98 percent / sulfuric acid / 2 h / 60 °C
View Scheme
参考文献
Hill, Ronald A.; Rudra, Sonali; Peng, Bo; Roane, David S.; Bounds, Jeffrey K.; Zhang, Yang; Adloo, Ahmad; Lu, Tiansheng
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 9 p. 2099 - 2113
反应条件
1: 80 percent / aq. NaOH, Br2 / 0.5 h / 50 - 60 °C
2: 70 percent / NaH, Cu2Br2
View Scheme
参考文献
Weimar; Van Angerer; Wiegrebe
Archiv der Pharmazie, 1991 , vol. 324, # 8 p. 509 - 518
反应条件
copper(I) bromide; sodium hydride
参考文献
Weimar; Van Angerer; Wiegrebe
Archiv der Pharmazie, 1991 , vol. 324, # 8 p. 509 - 518
反应条件
1: Raney nickel; methanol / 91938.4 Torr / Hydrogenation
2: aqueous sulfuric acid
3: aq. NaOH solution / Erhitzen des Reaktionsgemisches mit wss. Natronlauge
View Scheme
参考文献
Ungnade; Nightingale; French
Journal of Organic Chemistry, 1945 , vol. 10, p. 533,534
反应条件
1: aqueous sulfuric acid
2: aq. NaOH solution / Erhitzen des Reaktionsgemisches mit wss. Natronlauge
View Scheme
参考文献
Horeau; Jacques
Bulletin de la Societe Chimique de France, 1948 , p. 53,58
Full Text Show Details
Ungnade; Nightingale; French
Journal of Organic Chemistry, 1945 , vol. 10, p. 533,534
反应条件
1: sodium; copper(I) bromide / 12 h / 70 °C
2: water; lithium hydroxide hydrate / methanol / 12 h / 40 °C
3: toluene / 12 h / 105 °C
View Scheme
参考文献
AbbVie Inc.; Abbott GmbH and Co. KG; Geneste, Hervé; Ochse, Michael; Drescher, Karla; Dinges, Jürgen; Jakob, Clarissa
Patent: US2013/116229 A1, 2013 ;
反应条件
1: water; lithium hydroxide hydrate / methanol / 12 h / 40 °C
2: toluene / 12 h / 105 °C
View Scheme
参考文献
AbbVie Inc.; Abbott GmbH and Co. KG; Geneste, Hervé; Ochse, Michael; Drescher, Karla; Dinges, Jürgen; Jakob, Clarissa
Patent: US2013/116229 A1, 2013 ;
反应条件
potassium hydroxide
T=0°C; Hydrogenation;
参考文献
Kamal; Warsi
Pakistan J. scient. Res., 1951 , vol. 3, p. 41
