2,3-二甲基-4-硝基苯甲腈合成路线 （共 12 条）
反应条件
1: H2SO4 2: H2SO4, aq. NaNO2 3: H2SO4 / Heating 4: SnCl2, aq. HCl, AcOH 5: aq. NaNO2, aq. H2SO4 6: aq. NaOH 7: aq. NaOH View Scheme
参考文献
Vene,J. et al.
Bulletin de la Societe Chimique de France, 1963 , p. 1813 - 1817
反应条件
1: H2SO4 2: H2SO4, aq. NaNO2 3: aq. NH3, aq. FeSO4 / Heating View Scheme
参考文献
Vene,J. et al.
Bulletin de la Societe Chimique de France, 1963 , p. 1813 - 1817
反应条件
tetrakistriphenylphosphine in tetrahydrofuran
10 h; Heating / reflux;
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: EP1403255 A1, 2004 ;
Location in patent: Page 127-128 ;
EP 1403255 A1
反应条件
sulfuric acid
T=25°C;
参考文献
Bloomfield, Colin; Moodie, Roy B.; Schofield, Kenneth
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1983 , p. 1003 - 1010
反应条件
1: HNO3, H2SO4
2: (i) NaNO2, aq. HCl, (ii) /BRN= 4652394/, aq. CuSO4
View Scheme
参考文献
Vene,J. et al.
Bulletin de la Societe Chimique de France, 1963 , p. 1813 - 1817
反应条件
sulfuric acid; nitric acid
T=0°C; 1 h; Rate constantProduct distribution;
参考文献
Bloomfield, Colin; Moodie, Roy B.; Schofield, Kenneth
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1983 , p. 1003 - 1010
反应条件
(i) NaNO2, aq. HCl, (ii) /BRN= 4652394/, aq. CuSO4; Multistep reaction;
参考文献
Vene,J. et al.
Bulletin de la Societe Chimique de France, 1963 , p. 1813 - 1817
反应条件
sulfuric acid; 4-aminobenzenesulfonic acid
T=25°C; Rate constantProduct distributionMechanism;
参考文献
Bloomfield, Colin; Moodie, Roy B.; Schofield, Kenneth
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1983 , p. 1003 - 1010
反应条件
1: H2SO4
2: H2SO4, aq. NaNO2
3: aq. NH3, aq. FeSO4 / Heating
4: aq. H2SO4, aq. NaNO2
View Scheme
参考文献
Vene,J. et al.
Bulletin de la Societe Chimique de France, 1963 , p. 1813 - 1817
反应条件
1: H2SO4
2: H2SO4, aq. NaNO2
3: H2SO4 / Heating
4: SnCl2, aq. HCl, AcOH
5: aq. NaNO2, aq. H2SO4
6: aq. NaOH
View Scheme
参考文献
Vene,J. et al.
Bulletin de la Societe Chimique de France, 1963 , p. 1813 - 1817
