2-(4-乙氧基-3-甲氧基苯基)-1,3-二氧戊环合成路线 （共 3 条）
反应条件
1: With lithium diphenylphosphinide in tetrahydrofuran T=20°C; 3 - 4 h; 2: With sodium hydroxide; water in tetrahydrofuran 3: With hydrogenchloride; water pH=3 - 4;
参考文献
Zhejiang Dade Pharmaceutical Group Co., Ltd.
Patent: EP2065358 A1, 2009 ;
Location in patent: Page/Page column 11; 19 ;
反应条件
1: With orthoformic acid triethyl ester; boron trifluoride diethyl etherate in diethyl ether
T=100°C; 24 h; Heating / reflux;
2: With sodium hydroxide; water in diethyl ether
T=20°C;
参考文献
Zhejiang Dade Pharmaceutical Group Co., Ltd.
Patent: EP2065358 A1, 2009 ;
Location in patent: Page/Page column 11; 19 ;
反应条件
1.1: sodium hydroxide / 18-crown-6 ether / isopropyl alcohol; water / 0.5 h
1.2: 60 °C
2.1: orthoformic acid triethyl ester / boron trifluoride diethyl etherate / 24 h / 100 °C / Inert atmosphere
View Scheme
参考文献
Shanghai Ecust Biomedicine Co., Ltd; Zhejiang Wild Wind Pharmaceutical Co., Ltd
Patent: EP2351730 A1, 2011 ;
