1,3-二乙基-5,6-二氨基尿嘧啶合成路线 （共 16 条）
反应条件
ammonium hydroxide; sodium dithionite in water 0.5 h;
参考文献
Joerg, Manuela; Shonberg, Jeremy; Mak, Frankie S.; Miller, Neil D.; Yuriev, Elizabeth; Scammells, Peter J.; Capuano, Ben
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3427 - 3433
反应条件
1: With nitric acid; acetic acid in water 2: With sodium dithionite; ammonia in water Further stages.;
参考文献
Labeaume, Paul; Dong, Ma; Sitkovsky, Michail; Jones, Elizabeth V.; Thomas, Rhiannon; Sadler, Sara; Kallmerten, Amy E.; Jones, Graham B.
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 18 p. 4155 - 4157
反应条件
1.1: Ac2O / 70 °C 2.1: aq. AcOH / 0.5 h / 75 °C 2.2: NaNO2 / 1 h / 20 °C 3.1: aq. NH3 / 0.5 h / 70 °C 3.2: Na2S2O4 / 0.5 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 12 p. 3682 - 3692
反应条件
1: acetic acid / 2 h / 80 °C 2: sodium nitrite / acetic acid / 0.25 h / 50 - 60 °C 3: ammonium hydroxide; sodium dithionite / water / 0.5 h View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 11 p. 3427 - 3433
反应条件
1: 1) 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 2) 1N NaOH / 1) dioxane, H2O, 2) dioxane, H2O, reflux 2: K2CO3 / dimethylformamide / 50 °C View Scheme
参考文献
Jacobson; Gallo-Rodriguez; Melman; Fischer; Maillard; Van Bergen; Van Galen; Karton
Journal of Medicinal Chemistry, 1993 , vol. 36, # 10 p. 1333 - 1342
反应条件
bromo-dimethylsulfonium bromide in acetonitrile T=20°C;
参考文献
Labeaume, Paul; Dong, Ma; Sitkovsky, Michail; Jones, Elizabeth V.; Thomas, Rhiannon; Sadler, Sara; Kallmerten, Amy E.; Jones, Graham B.
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 18 p. 4155 - 4157
反应条件
sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride 1) dioxane, H2O, 2) dioxane, H2O, reflux; Multistep reaction;
参考文献
Kyowa Hakko Kogyo Co., Ltd.
Patent: US5484920 A1, 1996 ;
US 5484920 A
反应条件
bromo-dimethylsulfonium bromide in acetonitrile T=25°C; 4 h; Inert atmosphere;
参考文献
Labeaume, Paul; Dong, Ma; Sitkovsky, Michail; Jones, Elizabeth V.; Thomas, Rhiannon; Sadler, Sara; Kallmerten, Amy E.; Jones, Graham B.
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 18 p. 4155 - 4157
反应条件
1: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in 1,4-dioxane; water 2: With sodium hydroxide Heating;
参考文献
Petzer, Jacobus P.; Steyn, Salome; Castagnoli, Kay P.; Chen, Jiang-Fan; Schwarzschild, Michael A.; Van Der Schyf, Cornelis J.; Castagnoli, Neal
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 7 p. 1299 - 1310
反应条件
1: 65 percent / pyridine / CH2Cl2 / 16 h / 20 °C 2: 92 percent / 1,1,1,3,3,3-hyxamethyldisilazane; (NH4)2SO4 / 4 h / 170 - 180 °C View Scheme
参考文献
Joerg, Manuela; Shonberg, Jeremy; Mak, Frankie S.; Miller, Neil D.; Yuriev, Elizabeth; Scammells, Peter J.; Capuano, Ben
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3427 - 3433
