1,3-二乙基-5,6-二氨基尿嘧啶合成路线 （共 16 条）
参考文献
Kyowa Hakko Kogyo Co., Ltd.
Patent: US5543415 A1, 1996 ;
反应条件
sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride 1) dioxane, H2O, 2) dioxane, H2O, reflux; Multistep reaction;
参考文献
Shimada, Junichi; Koike, Nobuaki; Nonaka, Hiromi; Shiozaki, Shizuo; Yanagawa, Koji; Kanda, Tomoyuki; Kobayashi, Hiroyuki; Ichimura, Michio; Nakamura, Joji; Kase, Hiroshi; Suzuki, Fumio
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 18 p. 2349 - 2352
反应条件
1.1: EDAC / dioxane; H2O 1.2: 27 percent / aq. NaOH / Heating 2.1: 87.6 percent / K2CO3 / dimethylformamide View Scheme
参考文献
Van Der Walt, Mietha M.; Terre'Blanche, Gisella; Petzer, Anel; Lourens, Anna C.U.; Petzer, Jacobus P.
Bioorganic Chemistry, 2013 , vol. 49, p. 49 - 58
反应条件
1: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in 1,4-dioxane; water 2: With sodium hydroxide Heating;
参考文献
Petzer, Jacobus P.; Steyn, Salome; Castagnoli, Kay P.; Chen, Jiang-Fan; Schwarzschild, Michael A.; Van Der Schyf, Cornelis J.; Castagnoli, Neal
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 7 p. 1299 - 1310
反应条件
1: 65 percent / pyridine / CH2Cl2 / 16 h / 20 °C 2: 92 percent / 1,1,1,3,3,3-hyxamethyldisilazane; (NH4)2SO4 / 4 h / 170 - 180 °C 3: 95 percent / potassium carbonate / dimethylformamide / 0.5 h / 20 °C View Scheme
参考文献
Shimada, Junichi; Koike, Nobuaki; Nonaka, Hiromi; Shiozaki, Shizuo; Yanagawa, Koji; Kanda, Tomoyuki; Kobayashi, Hiroyuki; Ichimura, Michio; Nakamura, Joji; Kase, Hiroshi; Suzuki, Fumio
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 18 p. 2349 - 2352
反应条件
toluene-4-sulfonic acid in trimethyl orthoformate
参考文献
Bayer Aktiengesellschaft
Patent: US5714494 A1, 1998 ;
US 5714494 A
