反应条件
1.1: p-TsOH / toluene / 14 h / Heating 2.1: NaH / dimethylformamide / 0 °C 2.2: 19.5 g / dimethylformamide / 16 h / 20 °C 3.1: sec-BuLi / tetrahydrofuran / 2 h / -78 °C 3.2: 86 percent / tetrahydrofuran / 1 h / -78 - 0 °C 4.1: Na2HPO4; m-chloroperbenzoic acid / CH2Cl2; CHCl3 / 1 h / 20 °C 5.1: 13.8 g / NaOH / methanol / 2 h 6.1: K2CO3; tetrabutylammonium iodide / dimethylformamide / 72 h / 20 °C 7.1: 1.45 g / aq. HCl / tetrahydrofuran / 1 h View Scheme
参考文献
Leese, Mathew P.; Hejaz, Hatem A. M.; Mahon, Mary F.; Newman, Simon P.; Purohit, Atul; Reed, Michael J.; Potter, Barry V. L.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 16 p. 5243 - 5256