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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
嘌呤霉素
合成路线
（共 20 条）
57182-86-2
→
反应条件
53-79-2
嘌呤霉素
反应条件
hydrogen; palladium on activated charcoal in ethanol Hydrogenolysis; 5 h;
参考文献
Mehrotra, Amit P.; Ryan, Martin D.; Gani, David
Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 6 p. 623 - 634
57183-05-8
→
反应条件
53-79-2
嘌呤霉素
反应条件
trifluoroacetic acid T=20°C; 0.133333 h;
参考文献
Robins, Morris J.; Miles, Robert W.; Samano, Mirna C.; Kaspar, Roger L.
Journal of Organic Chemistry, 2001 , vol. 66, # 24 p. 8204 - 8210
67313-10-4
→
反应条件
53-79-2
嘌呤霉素
反应条件
1: 92 percent / NH4HCO2 / Pd(OH)2-C / H2O; methanol / 1.5 h / Heating 2: pyridine / 48 h / 5 °C 3: 59.4 mg / TMSCl / pyridine 4: 25.8 mg / pyridine; H2O / 19 h / 20 °C 5: 62 percent / DCC; N-hydroxysuccinimide / dimethylformamide / 0 - 20 °C 6: 36 percent / TFA / 0.13 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 66, # 24 p. 8204 - 8210
2627-64-7
[(1R,2R,4R,5R)-2-(6-氨基嘌呤-9-基)-3,6-二氧杂双环[3.1.0]己烷-4-基]甲醇
→
反应条件
53-79-2
嘌呤霉素
反应条件
1: 100 percent / pyridine / 12 h / 20 °C 2: 95 percent / Me2BBr; Et3N / CH2Cl2 / 1 h / -78 °C 3: 89 percent / Et3N / tetrahydrofuran; acetonitrile / 48 h / 20 °C 4: NaH / tetrahydrofuran / 12 h / -20 °C 5: 112 mg / TBAF / tetrahydrofuran / 1 h / 20 °C 6: 92 percent / NaOH; H2O / tetrahydrofuran / 48 h / 20 °C 7: 92 percent / NH4HCO2 / Pd(OH)2-C / H2O; methanol / 1.5 h / Heating 8: pyridine / 48 h / 5 °C 9: 59.4 mg / TMSCl / pyridine 10: 25.8 mg / pyridine; H2O / 19 h / 20 °C 11: 62 percent / DCC; N-hydroxysuccinimide / dimethylformamide / 0 - 20 °C 12: 36 percent / TFA / 0.13 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 66, # 24 p. 8204 - 8210
125084-71-1
→
反应条件
53-79-2
嘌呤霉素
反应条件
1: 92 percent / NaOH; H2O / tetrahydrofuran / 48 h / 20 °C 2: 92 percent / NH4HCO2 / Pd(OH)2-C / H2O; methanol / 1.5 h / Heating 3: pyridine / 48 h / 5 °C 4: 59.4 mg / TMSCl / pyridine 5: 25.8 mg / pyridine; H2O / 19 h / 20 °C 6: 62 percent / DCC; N-hydroxysuccinimide / dimethylformamide / 0 - 20 °C 7: 36 percent / TFA / 0.13 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 66, # 24 p. 8204 - 8210
125084-70-0
→
反应条件
53-79-2
嘌呤霉素
反应条件
1: 95 percent / Me2BBr; Et3N / CH2Cl2 / 1 h / -78 °C 2: 89 percent / Et3N / tetrahydrofuran; acetonitrile / 48 h / 20 °C 3: NaH / tetrahydrofuran / 12 h / -20 °C 4: 112 mg / TBAF / tetrahydrofuran / 1 h / 20 °C 5: 92 percent / NaOH; H2O / tetrahydrofuran / 48 h / 20 °C 6: 92 percent / NH4HCO2 / Pd(OH)2-C / H2O; methanol / 1.5 h / Heating 7: pyridine / 48 h / 5 °C 8: 59.4 mg / TMSCl / pyridine 9: 25.8 mg / pyridine; H2O / 19 h / 20 °C 10: 62 percent / DCC; N-hydroxysuccinimide / dimethylformamide / 0 - 20 °C 11: 36 percent / TFA / 0.13 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 66, # 24 p. 8204 - 8210
125084-68-6
→
反应条件
53-79-2
嘌呤霉素
反应条件
1: 89 percent / Et3N / tetrahydrofuran; acetonitrile / 48 h / 20 °C 2: NaH / tetrahydrofuran / 12 h / -20 °C 3: 112 mg / TBAF / tetrahydrofuran / 1 h / 20 °C 4: 92 percent / NaOH; H2O / tetrahydrofuran / 48 h / 20 °C 5: 92 percent / NH4HCO2 / Pd(OH)2-C / H2O; methanol / 1.5 h / Heating 6: pyridine / 48 h / 5 °C 7: 59.4 mg / TMSCl / pyridine 8: 25.8 mg / pyridine; H2O / 19 h / 20 °C 9: 62 percent / DCC; N-hydroxysuccinimide / dimethylformamide / 0 - 20 °C 10: 36 percent / TFA / 0.13 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 66, # 24 p. 8204 - 8210
125127-12-0
→
反应条件
53-79-2
嘌呤霉素
反应条件
1: 112 mg / TBAF / tetrahydrofuran / 1 h / 20 °C 2: 92 percent / NaOH; H2O / tetrahydrofuran / 48 h / 20 °C 3: 92 percent / NH4HCO2 / Pd(OH)2-C / H2O; methanol / 1.5 h / Heating 4: pyridine / 48 h / 5 °C 5: 59.4 mg / TMSCl / pyridine 6: 25.8 mg / pyridine; H2O / 19 h / 20 °C 7: 62 percent / DCC; N-hydroxysuccinimide / dimethylformamide / 0 - 20 °C 8: 36 percent / TFA / 0.13 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 66, # 24 p. 8204 - 8210
125084-69-7
→
反应条件
53-79-2
嘌呤霉素
反应条件
1: NaH / tetrahydrofuran / 12 h / -20 °C 2: 112 mg / TBAF / tetrahydrofuran / 1 h / 20 °C 3: 92 percent / NaOH; H2O / tetrahydrofuran / 48 h / 20 °C 4: 92 percent / NH4HCO2 / Pd(OH)2-C / H2O; methanol / 1.5 h / Heating 5: pyridine / 48 h / 5 °C 6: 59.4 mg / TMSCl / pyridine 7: 25.8 mg / pyridine; H2O / 19 h / 20 °C 8: 62 percent / DCC; N-hydroxysuccinimide / dimethylformamide / 0 - 20 °C 9: 36 percent / TFA / 0.13 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 66, # 24 p. 8204 - 8210
58-60-6
氨基核苷嘌呤霉素
→
反应条件
53-79-2
嘌呤霉素
反应条件
1: 62 percent / DCC; N-hydroxysuccinimide / dimethylformamide / 0 - 20 °C 2: 36 percent / TFA / 0.13 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 66, # 24 p. 8204 - 8210
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