反应条件
1: malonic acid ethyl ester monopotassium salt With magnesium chloride in N,N-dimethyl-formamide T=60°C; 4 h; 2: pyridazine-4-carboxylic acid; 1,1'-carbonyldiimidazole in N,N-dimethyl-formamide T=20°C; 4 h; 3: in N,N-dimethyl-formamide T=20°C; 26 h;
参考文献
Nippon Shinyaku Co., Ltd.
Patent: EP1533304 A1, 2005 ;
Location in patent: Page/Page column 19 ;
EP 1533304 A1