2-甲氧基-6-甲基苯甲腈合成路线 （共 15 条）
反应条件
1,1'-carbonyldiimidazole in dichloromethane T=20°C; 15 h;
参考文献
Rhizen Pharmaceuticals SA
Patent: US2012/289496 A1, 2012 ;
Location in patent: Page/Page column 115 ;
反应条件
in N,N-dimethyl-formamide T=150°C;
参考文献
WO2013/62892 A1, ;
Page/Page column 40; 41 ;
反应条件
pyridine; trifluoroacetic anhydride in dichloromethane Ambient temperature;
参考文献
Fisher, Lawrence E.; Muchowski, Joseph M.; Clark, Robin D.
Journal of Organic Chemistry, 1992 , vol. 57, # 9 p. 2700 - 2705
反应条件
sodium peroxodisulphate; palladium diacetate T=20 - 70°C; 24 h; Inert atmosphere;
参考文献
Li, Wu; Sun, Peipei
Journal of Organic Chemistry, 2012 , vol. 77, # 18 p. 8362 - 8366
反应条件
1: 91 percent / LDA / tetrahydrofuran; hexane / -70 deg C, 10 min, then to 0 deg C 2: 1.) tert-butyllithium / 1.) THF, pentane, -100 deg C, 10 min , then to -70 deg C 2.) THF, to 0 deg C 3: 86 percent / 50 percent aq. acetic acid / 60 °C 4: 91 percent / trifluoroacetic anhydride, pyridine / CH2Cl2 / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 57, # 9 p. 2700 - 2705
反应条件
1: 1.) tert-butyllithium / 1.) THF, pentane, -100 deg C, 10 min , then to -70 deg C 2.) THF, to 0 deg C 2: 86 percent / 50 percent aq. acetic acid / 60 °C 3: 91 percent / trifluoroacetic anhydride, pyridine / CH2Cl2 / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 57, # 9 p. 2700 - 2705
反应条件
1: 86 percent / 50 percent aq. acetic acid / 60 °C 2: 91 percent / trifluoroacetic anhydride, pyridine / CH2Cl2 / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 57, # 9 p. 2700 - 2705
反应条件
1: 2-methoxy-6-methylbenzenamine With sodium nitrite Diazotization; 2: copper (I) cyanide Substitution; Sandmeyer reaction;
参考文献
Schubert, Thomas; Kula, Maria-Regina; Mueller, Michael
Synthesis, 1999 , # 12 p. 2045 - 2048
反应条件
1: hydroxylamine hydrochloride; triethylamine / 3 h / 80 °C 2: 1,1'-carbonyldiimidazole / dichloromethane / 15 h / 20 °C View Scheme
参考文献
WO2012/151525 A1, ;
WO 2012/151525 A1
US2012/289496 A1, ;
反应条件
1: sodium hydride / N,N-dimethyl-formamide / 0 °C 2: N,N-dimethyl-formamide / 24 h / 150 °C View Scheme
