3-乙酰基-2-氧杂环庚烷酮合成路线 （共 6 条）
反应条件
1: With n-butyllithium; diisopropylamine in tetrahydrofuran; hexanes
T=-78°C; 0.75 h;
2: ε-caprolactone in tetrahydrofuran; hexanes
T=-78°C; 1.25 h;
3: 2-oxopropionitrile in tetrahydrofuran; hexanes
T=-78°C; 0.166667 h;
参考文献
Roche Palo Alto LLC
Patent: US2004/224964 A1, 2004 ;
Location in patent: Page/Page column 45 ;
US 20040224964 A1
反应条件
titanium tetrachloride in dichloromethane
T=-70 - 23°C; Mukaiyama-type Claisen reaction; 1.5 h;
参考文献
Christoffers, Jens; Oertling, Heiko; Fischer, Peter; Frey, Wolfgang
Synlett, 2002 , # 6 p. 957 - 961
反应条件
Dess-Martin periodane
T=23°C; 1 h;
参考文献
Christoffers, Jens; Oertling, Heiko; Fischer, Peter; Frey, Wolfgang
Synlett, 2002 , # 6 p. 957 - 961
Title/Abstract Full Text View citing articles Show Details
Christoffers, Jens; Oertling, Heiko; Fischer, Peter; Frey, Wolfgang
Tetrahedron, 2003 , vol. 59, # 21 p. 3769 - 3778
反应条件
titanium tetrachloride in dichloromethane
T=-78 - 23°C;
参考文献
Christoffers, Jens; Oertling, Heiko; Fischer, Peter; Frey, Wolfgang
Tetrahedron, 2003 , vol. 59, # 21 p. 3769 - 3778
反应条件
1.1: lithium diisopropylamide / tetrahydrofuran / 1 h / -78 °C
1.2: 64 percent / tetrahydrofuran / -78 - 23 °C
2.1: 62 percent / molecular sieves 4 Angstroem; TiCl4 / CH2Cl2 / 21.5 h / -78 - 23 °C
View Scheme
参考文献
Christoffers, Jens; Oertling, Heiko; Fischer, Peter; Frey, Wolfgang
Tetrahedron, 2003 , vol. 59, # 21 p. 3769 - 3778
反应条件
1: 67 percent / BF3*Et2O / CH2Cl2 / 2 h / -78 °C
2: 85 percent / Dess-Martin periodinane / 1 h / 23 °C
View Scheme
参考文献
Christoffers, Jens; Oertling, Heiko; Fischer, Peter; Frey, Wolfgang
Tetrahedron, 2003 , vol. 59, # 21 p. 3769 - 3778
